Myotube assembly on nanofibrous and micropatterned polymers

被引：255

作者：

Huang, NF

Patel, S

Thakar, RG

Wu, J

Hsiao, BS

Chu, B

Lee, RJ

Li, S

机构：

[1] Univ Calif Berkeley, Univ Calif San Francisco, Joint Grad Program Bioengn, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Ctr Tissue Bioengn, Berkeley, CA 94720 USA

[4] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA

[5] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

来源：

NANO LETTERS | 2006年 / 6卷 / 03期

关键词：

D O I：

10.1021/nl060060o

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Skeletal muscle consists of parallel bundles of myotubes formed by the fusion of myoblasts, We fabricated nanofibrous and micropatterned polymers as cell culture substrates to guide the morphogenesis of muscular tissue. The nanoscale and microscale topographic features regulate cell and cytoskeleton alignment, myotube assembly, myotube striation, and myoblast proliferation, This bottom-up approach from nanoscale to tissue level demonstrates the potential of nanofibrous polymers for engineering the assembly of cell and tissue structure.

引用

页码：537 / 542

页数：6

共 25 条

[1] Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells [J].