The THRombolysis and STatins (THRaST) study

被引：90

作者：

Cappellari, Manuel ^{[1
]}

Bovi, Paolo ^{[1
]}

Moretto, Giuseppe ^{[1
]}

Zini, Andrea ^{[2
]}

Nencini, Patrizia ^{[3
]}

Sessa, Maria ^{[4
,5
]}

Furlan, Mauro ^{[6
]}

Pezzini, Alessandro ^{[7
]}

Orlandi, Giovanni ^{[8
]}

Paciaroni, Maurizio ^{[9
,10
]}

Tassinari, Tiziana ^{[11
]}

Procaccianti, Gaetano ^{[12
]}

Di Lazzaro, Vincenzo ^{[13
]}

Bettoni, Luigi ^{[14
]}

Gandolfo, Carlo ^{[15
]}

Silvestrelli, Giorgio ^{[16
]}

Rasura, Maurizia ^{[17
]}

Martini, Giuseppe ^{[18
]}

Melis, Maurizio ^{[19
,20
]}

Calloni, Maria Vittoria ^{[21
]}

Chiodo-Grandi, Fabio ^{[22
]}

Beretta, Simone ^{[23
]}

Guarino, Maria ^{[24
]}

Altavista, Maria Concetta ^{[25
]}

Marcheselli, Simona ^{[26
]}

Galletti, Giampiero ^{[27
]}

Adobbati, Laura ^{[28
]}

Del Sette, Massimo ^{[29
]}

Mancini, Armando ^{[30
]}

Orrico, Daniele ^{[31
]}

Monaco, Serena ^{[32
]}

Cavallini, Anna ^{[33
]}

Sciolla, Rossella ^{[34
]}

Federico, Francesco ^{[35
]}

Scoditti, Umberto ^{[36
]}

Brusaferri, Fabio ^{[37
]}

Grassa, Claudio ^{[38
]}

Specchio, Luigi ^{[39
]}

Bongioanni, Maria Roberta ^{[40
]}

Sparaco, Marco ^{[41
]}

Zampolini, Mauro ^{[42
]}

Greco, Gabriele ^{[43
]}

Colombo, Rinaldo ^{[44
]}

Passarella, Bruno ^{[45
]}

Adami, Alessandro ^{[46
]}

Consoli, Domenico ^{[47
]}

Toni, Danilo ^{[48
]}

机构：

[1] Azienda Osped Univ Integrata, UO Neurol DAI Neurosci, SSO Stroke Unit, Verona, Italy

[2] AUSL Modena, Nuovo Osped Civile S Agostino Estense, Stroke Unit, Clin Neurol, Modena, Italy

[3] Univ Florence, Dept Neurol & Psychiat Sci, Florence, Italy

[4] Ist Sci San Raffaele, Dept Neurol, I-20132 Milan, Italy

[5] Ist Sci San Raffaele, Inst Expt Neurol, I-20132 Milan, Italy

[6] PO Imperia, SC Neurol, Imperia, Italy

[7] Univ Brescia, Clin Neurol, Dipartimento Sci Clin & Sperimentali, Brescia, Italy

[8] Azienda Osped Univ, Clin Neurol, Pisa, Italy

[9] Univ Perugia, Stroke Unit, I-06100 Perugia, Italy

[10] Univ Perugia, Div Cardiovasc Med, I-06100 Perugia, Italy

[11] Presidio Osped Ponente Pietra Ligure Albenga, Osped S Corona, SC Neurol, Ctr Ictus, Pietra Ligure Savona, Savona, Italy

[12] Azienda USL Bologna, IRCCS Ist Sci Neurol, Osped Maggiore, Neurol Stroke Unit, Bologna, Italy

[13] Policlicn Campus Biomed, UOC Neurol, Rome, Italy

[14] Azienda Osped Cremona, Div Neurol, Cremona, Italy

[15] Univ Genoa, Ctr Ictus, Genoa, Italy

[16] Azienda Osped Carlo Poma, SC Neurol, Stroke Unit, Mantua, Italy

[17] Univ Roma La Sapienza, Stroke Unit, Azienda Osped St Andrea, Rome, Italy

[18] Azienda Osped Univ Senese, UOC Stroke Unit, Siena, Italy

[19] AO Brotzu, SC Neurol, Cagliari, Italy

[20] AO Brotzu, Stroke Unit, Cagliari, Italy

[21] AO Osped Civile Legnano, UO Neurol, Stroke Unit, Milan, Italy

[22] Osp Cattinara, SC Clin Neurol, SS Stroke Unit, Trieste, Italy

[23] Univ Milano Bicocca, San Gerardo Hosp, Monza, Italy

[24] S Orsola Malpighi Univ Hosp, Neurol Unit, Bologna, Italy

[25] ACO San Filippo Neri, UOC Neurol, Rome, Italy

[26] Ist Clin Humanitas, Stroke Unit, Milan, Italy

[27] Osped GB Morgagni, UO Neurol, Stroke Unit, Forli, Italy

[28] Osped San Luca, Ist Auxol, Stroke Unit, UO Neurol, Milan, Italy

[29] St Andrea Hosp, Dept Neurol, Stroke Unit, La Spezia, Italy

[30] Osped Spirito Santo, Stroke Unit, Pescara, Italy

[31] Osped S Chiara, SC Neurol, Stroke Unit, Trento, Italy

[32] ARNAS, Osped Civ, Stroke Unit, Palermo, Italy

[33] IRCCS Fdn Ist Neurol C Mondini, UOC Malattie Cerebrovasc, Stroke Unit, Pavia, Italy

[34] AOU San Luigi, SCDU Neurol, Orbassano, Italy

[35] Policlin Bari, Clin Neurol, Stroke Unit, Bari, Italy

[36] Univ Parma, Azienda Osped, Dipartimento Neurosci, Stroke Unit, I-43100 Parma, Italy

[37] Osped Maggiore Crema, UO Neurol, Stroke Unit, Crema, Italy

[38] Fidenza, UOC Neurol, UOS Stroke Unit, Parma, Italy

[39] Azienda Osped Univ, SC Neurol Univ, Foggia, Italy

[40] Osped Martini, SC Neurol, Turin, Italy

[41] Azienda Osped G Rummo, Dipartimento Neurosci, SC Neurol, Stroke Unit, Benevento, Italy

[42] Osped San Giovanni Battista Torino, Unita Gravi Cerebrolesioni, Dipartimento Riabil, Perugia, Italy

[43] Osped Ramazzini, Dipartimento Integrato Neurosci, UO Neurol, Carpi, Italy

[44] Osped Lavagna, UO Neurol, Genoa, Italy

[45] Osped Perrino, UO Neurol, Brindisi, Italy

[46] Osped Sacro Cuore, Negrar Stroke Ctr, Negrar Verona, Italy

[47] G Jazzolino Hosp, Stroke Unit, Vibo Valentia, Italy

[48] Univ Roma La Sapienza, Dept Neurol & Psychiat, Rome, Italy

来源：

NEUROLOGY | 2013年 / 80卷 / 07期

关键词：

ACUTE ISCHEMIC-STROKE; INTRAVENOUS THROMBOLYSIS; ACUTE-PHASE; IMPACT; ATORVASTATIN; METAANALYSIS; SIMVASTATIN; IMPROVEMENT; ALTEPLASE;

D O I：

10.1212/WNL.0b013e318281cc83

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Objective: To assess the impact on stroke outcome of statin use in the acute phase after IV thrombolysis. Methods: Multicenter study on prospectively collected data of 2,072 stroke patients treated with IV thrombolysis. Outcome measures of efficacy were neurologic improvement (NIH Stroke Scale [NIHSS] <= 4 points from baseline or NIHSS = 0) and major neurologic improvement (NIHSS <= 8 points from baseline or NIHSS = 0) at 7 days and favorable (modified Rankin Scale [mRS] <= 2) and excellent functional outcome (mRS <= 1) at 3 months. Outcome measures of safety were 7-day neurologic deterioration (NIHSS >= 4 points from baseline or death), symptomatic intracerebral hemorrhage type 2 with NIHSS >= 4 points from baseline or death within 36 hours, and 3-month death. Results: Adjusted multivariate analysis showed that statin use in the acute phase was associated with neurologic improvement (odds ratio [OR] 1.68, 95% confidence interval [CI] 1.26-2.25; p < 0.001), major neurologic improvement (OR 1.43, 95% CI 1.11-1.85; p = 0.006), favorable functional outcome (OR 1.63, 95% CI 1.18-2.26; p = 0.003), and a reduced risk of neurologic deterioration (OR: 0.31, 95% CI 0.19-0.53; p < 0.001) and death (OR 0.48, 95% CI 0.28-0.82; p = 0.007). Conclusion: Statin use in the acute phase of stroke after IV thrombolysis may positively influence short-and long-term outcome. Neurology (R) 2013;80:655-661

引用

页码：655 / 661

页数：7

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