An early increase in cGMP follows fertilization of sea urchin eggs

被引:24
作者
Ciapa, B [1 ]
Epel, D [1 ]
机构
[1] STANFORD UNIV, HOPKINS MARINE STN, STANFORD, CA 94305 USA
关键词
D O I
10.1006/bbrc.1996.0946
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
It has been proposed that both inositol trisphosphate and ryanodine receptors contribute to the Ca signal generated at fertilization of the sea urchin egg. Pharmacological studies indicate that cyclic adenosine diphosphate-ribose (cADPr) is the endogenous modulator of Ca release by the ryanodine-like receptor in eggs and that cADPR cyclase, the enzyme responsible for cADPR synthesis, can be stimulated by 3',5'-cyclic guanosine monophosphate (cGMP). Also, recent results show that the gaseous transmitter nitric oxide (NO) releases calcium in eggs via a mechanism linked to cGMP and cADPR production. Results reported here show that fertilization induces a rapid and transient increase in the intracellular concentration of cGMP. This increase occurs during the latent period, before the major increase in cytoplasmic free calcium (Ca-i), consistent with the hypothesis that cGMP production may play a key role in the Ca signal seen at fertilization. (C) 1996 Academic Press, Inc.
引用
收藏
页码:633 / 636
页数:4
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