Malignant transformation by the eukaryotic translation initiation factor 3 subunit p48 (eIF3e)

被引：75

作者：

Mayeur, GL ^{[1
]}

Hershey, JWB ^{[1
]}

机构：

[1] Univ Calif Davis, Sch Med, Dept Biol Chem, Davis, CA 95616 USA

来源：

FEBS LETTERS | 2002年 / 514卷 / 01期

关键词：

protein synthesis; translation initiation; eIF3; Int6; malignant transformation;

D O I：

10.1016/S0014-5793(02)02307-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several components of translation, e.g. cIF4E and PKR, are implicated in cancer. The e-subunit (p48) of mammalian initiation factor 3 is encoded by the Int6 gene, a common site for integration of the mouse mammary tumor virus genome, leading to the production of a truncated eukaryotic initiation factor-3e (eIF3e). Stable expression of a truncated eIF3e in NIH 3T3 cells causes malignant transformation by four criteria: foci formation; anchorage independent growth; accelerated growth; and lack of contact inhibition. Stable expression of full-length eIF3e does not cause transformation. The truncated eIF3e also inhibits the onset of apoptosis caused by serum starvation. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：49 / 54

页数：6

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