Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder

被引:122
作者
Bengel, D
Greenberg, BD
Corá-Locatelli, G
Altemus, M
Heils, A
Li, Q
Murphy, DL
机构
[1] Univ Wurzburg, Dept Psychiat, D-97080 Wurzburg, Germany
[2] NIMH, Clin Sci Lab, NIH, Bethesda, MD 20892 USA
关键词
obsessive-compulsive disorder; genetics; serotonin transporter; association study;
D O I
10.1038/sj.mp.4000550
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Although modulation of symptoms of obsessive-compulsive disorder (OCD) by serotonergic agents is well established, it is unclear whether an abnormality in the central serotonergic system is involved in its etiology. The serotonin (5-HT) transporter (5-HTT), which is the key modulator of serotonergic neurotransmission, is the target for serotonin reuptake inhibiting drugs (SRIs) that are uniquely effective in the treatment of OCD. In this preliminary study we report an association of a functional polymorphism in the 5HTT 5' regulatory-region and OCD. Seventy-five OCD Caucasian patients and 397 ethnically-matched individuals from a non-patient control group were genotyped for the 5-HTTLPR. Population-based association analysis revealed that patients with OCD were more likely to carry two copies of the long allele (I) as compared to controls (46.7% vs 32.3%: chi(2) = 5.19, P = 0.023). This finding replicates a recent family-based study of this polymorphism in OCD, and thus indicates that the 5-HTTLPR may be associated with susceptibility to OCD.
引用
收藏
页码:463 / 466
页数:4
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