Novel α-glucosidase inhibitors, CKD-711 and CKD-711a produced by Streptomyces sp CK-4416I.: Taxonomy, fermentation and isolation

被引：7

作者：

Kim, JG ^{[1
]}

Chang, HB ^{[1
]}

Kwon, YI ^{[1
]}

Moon, SK ^{[1
]}

Chun, HS ^{[1
]}

Ahn, SK ^{[1
]}

Hong, CI ^{[1
]}

机构：

[1] CKD Res Inst, Cheonan 330600, South Korea

来源：

JOURNAL OF ANTIBIOTICS | 2002年 / 55卷 / 05期

关键词：

D O I：

10.7164/antibiotics.55.457

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

New alpha-glucosidase inhibitors, CKD-711 and CKD-711a were produced from the fermentation broth of Streptomyces sp. CK-4416 which was isolated from a forest soil of Jeju Island, South Korea. CKD-711 and CKD-711a were purified by Dowex 50W-2X and Sephadex G-10 column chromatography. In in vitro studies, CKD-711 showed a potent inhibitory activity against alpha-glucosidase from mammalian, but less inhibition against alpha-amylase from microorganism and mammalian, CKD-711a showed a lower inhibitory activity than CKD-711.

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页码：457 / 461

页数：5

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