Pubertal hormones modulate the addition of new cells to sexually dimorphic brain regions

被引：227

作者：

Ahmed, Eman I. ^{[1
]}

Zehr, Julia L. ^{[1
]}

Schulz, Kalynn M. ^{[1
,2
]}

Lorenz, Betty H. ^{[3
,4
]}

DonCarlos, Lydia L. ^{[3
]}

Sisk, Cheryl L. ^{[1
,2
]}

机构：

[1] Michigan State Univ, Neurosci Program, E Lansing, MI 48824 USA

[2] Michigan State Univ, Dept Psychol, E Lansing, MI 48824 USA

[3] Loyola Univ, Stritch Sch Med, Dept Cell Biol Neurobiol & Anat, Maywood, IL 60153 USA

[4] Loyola Univ, Stritch Sch Med, Neurosci Program, Maywood, IL 60153 USA

来源：

NATURE NEUROSCIENCE | 2008年 / 11卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nn.2178

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

New cells, including neurons, arise in several brain regions during puberty in rats. Sex differences in pubertal addition of cells coincide with adult sexual dimorphisms: for each region, the sex that gains more cells during puberty has a larger volume in adulthood. Removing gonadal hormones before puberty eliminates these sex differences, indicating that gonadal steroids direct the addition of new cells during puberty to maintain and accentuate sexual dimorphisms in the adult brain.

引用

页码：995 / 997

页数：3

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