EBV-specific cytotoxic T lymphocytes protect against human EBV-associated lymphoma in scid mice

被引：22

作者：

Buchsbaum, RJ

Fabry, JA

Lieberman, J

机构：

[1] TUFTS UNIV NEW ENGLAND MED CTR,DEPT MED,DIV HEMATOL ONCOL,BOSTON,MA 02111

[2] HARVARD UNIV,SCH MED,CTR BLOOD RES,BOSTON,MA 02115

来源：

IMMUNOLOGY LETTERS | 1996年 / 52卷 / 2-3期

关键词：

Epstein-Barr virus (EBV); cytotoxic T lymphocyte (CTL); lymphoma; scid mice;

D O I：

10.1016/0165-2478(96)02602-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Scid mice develop human EBV-positive B cell tumors after injection with EBV-transformed human B cells or peripheral blood lymphocytes from EBV-seropositive donors. Injection of cytotoxic T cell (CTL) lines, selectively expanded in vitro to recognize autologous EBV-transformed B cells, protected mice against developing human lymphoproliferative disease. CTL protection required a single dose of polyethylene-glycol-conjugated IL2. Mice were not protected by CTL that did not specifically recognize EBV-transformed B cells or by mitogen-activated lymphocytes.

引用

收藏

页码：145 / 152

页数：8

相关论文

共 35 条

[1] LOW-DOSE INTERLEUKIN-2 PREVENTS THE DEVELOPMENT OF EPSTEIN-BARR-VIRUS (EBV)-ASSOCIATED LYMPHOPROLIFERATIVE DISEASE IN SCID/SCID MICE RECONSTITUTED IP WITH EBV-SEROPOSITIVE HUMAN PERIPHERAL-BLOOD LYMPHOCYTES [J].

BAIOCCHI, RA ;

CALIGIURI, MA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (12) :5577-5581

[2] A SEVERE COMBINED IMMUNODEFICIENCY MUTATION IN THE MOUSE [J].

BOSMA, GC ;

CUSTER, RP ;

BOSMA, MJ .

NATURE, 1983, 301 (5900) :527-530

[3]

BOYLE TJ, 1993, SURGERY, V114, P218

[4]

BUCHSBAUM RB, 1993, BLOOD S1, V82, pS560

[5] QUANTITATIVE-ANALYSIS OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1)-SPECIFIC CYTOTOXIC LYMPHOCYTE-T (CTL) RESPONSE AT DIFFERENT STAGES OF HIV-1 INFECTION - DIFFERENTIAL CTL RESPONSES TO HIV-1 AND EPSTEIN-BARR-VIRUS IN LATE DISEASE [J].

CARMICHAEL, A ;

JIN, X ;

SISSONS, P ;

BORYSIEWICZ, L .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (02) :249-256

[6] EXPRESSION OF THE HTLV-III ENVELOPE GENE BY A RECOMBINANT VACCINIA VIRUS [J].

CHAKRABARTI, S ;

ROBERTGUROFF, M ;

WONGSTAAL, F ;

GALLO, RC ;

MOSS, B .

NATURE, 1986, 320 (6062) :535-537

[7] IDENTIFICATION OF HERPESVIRUS-LIKE DNA-SEQUENCES IN AIDS-ASSOCIATED KAPOSIS-SARCOMA [J].

CHANG, Y ;

CESARMAN, E ;

PESSIN, MS ;

LEE, F ;

CULPEPPER, J ;

KNOWLES, DM ;

MOORE, PS .

SCIENCE, 1994, 266 (5192) :1865-1869

[8] MULTIPLE HLA A11-RESTRICTED CYTOTOXIC LYMPHOCYTE-T EPITOPES OF DIFFERENT IMMUNOGENICITIES IN THE EPSTEIN-BARR VIRUS-ENCODED NUCLEAR ANTIGEN-4 [J].

GAVIOLI, R ;

KURILLA, MG ;

DECAMPOSLIMA, PO ;

WALLACE, LE ;

DOLCETTI, R ;

MURRAY, RJ ;

RICKINSON, AB ;

MASUCCI, MG .

JOURNAL OF VIROLOGY, 1993, 67 (03) :1572-1578

[9] ADOPTIVE TRANSFER OF POLYCLONAL AND CLONED CYTOLYTIC T-LYMPHOCYTES (CTL) SPECIFIC FOR MOUSE AIDS-ASSOCIATED TUMORS IS EFFECTIVE IN PRESERVING CTL RESPONSES - A MEASURE OF PROTECTION AGAINST LP-BMS RETROVIRUS-INDUCED IMMUNODEFICIENCY [J].

GREEN, WR ;

GREEN, KA ;

CRASSI, KM .

JOURNAL OF VIROLOGY, 1994, 68 (07) :4679-4684

[10] Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes [J].

Heslop, HE ;

Ng, CYC ;

Li, CF ;

Smith, CA ;

Loftin, SK ;

Krance, RA ;

Brenner, MK ;

Rooney, CM .

NATURE MEDICINE, 1996, 2 (05) :551-555

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