Salivary progesterone and estriol among pregnant women treated with 17-α-hydroxyprogesterone caproate or placebo

被引：21

作者：

Klebanoff, Mark A. ^{[1
]}

Meis, Paul J. ^{[3
]}

Dombrowski, Mitchell P. ^{[4
]}

Zhao, Yuan ^{[2
]}

Moawad, Atef H. ^{[5
]}

Northen, Allison ^{[6
]}

Sibai, Baha M. ^{[7
,8
]}

Iams, Jay D. ^{[9
]}

Varner, Michael W. ^{[10
]}

Caritis, Steve N. ^{[11
]}

O'Sullivan, Mary J. ^{[12
]}

Leveno, Kenneth J. ^{[13
]}

Miodovnik, Menachem ^{[14
,15
]}

Conway, Deborah ^{[16
]}

Wapner, Ronald J. ^{[14
,17
]}

Carpenter, Marshall ^{[18
]}

Mercer, Brian M. ^{[19
]}

Ramin, Susan M. ^{[20
]}

Thorp, John M. ^{[21
]}

Peaceman, Alan M. ^{[22
]}

机构：

[1] NICHHD, Bethesda, MD 20892 USA

[2] George Washington Univ, Ctr Biostat, Washington, DC USA

[3] Wake Forest Univ, Dept Obstet & Gynecol, Winston Salem, NC 27109 USA

[4] Wayne State Univ, Detroit, MI USA

[5] Univ Chicago, Chicago, IL 60637 USA

[6] Univ Alabama, Birmingham, AL USA

[7] Univ Cincinnati, Cincinnati, OH USA

[8] Univ Tennessee, Memphis, TN USA

[9] Ohio State Univ, Columbus, OH 43210 USA

[10] Univ Utah, Salt Lake City, UT USA

[11] Univ Pittsburgh, Pittsburgh, PA USA

[12] Univ Miami, Miami, FL USA

[13] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA

[14] Columbia Univ, New York, NY USA

[15] Washington Hosp Ctr, Washington, DC 20010 USA

[16] Univ Texas San Antonio, San Antonio, TX USA

[17] Drexel Univ, Philadelphia, PA 19104 USA

[18] Brown Univ, Providence, RI 02912 USA

[19] Case Western Reserve Univ, Cleveland, OH 44106 USA

[20] Univ Texas Houston, Houston, TX USA

[21] Univ N Carolina, Chapel Hill, NC USA

[22] Northwestern Univ, Chicago, IL 60611 USA

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2008年 / 199卷 / 05期

关键词：

17-alpha-hydroxyprogesterone caproate; longitudinal studies; preterm birth; salivary estriol; salivary progesterone;

D O I：

10.1016/j.ajog.2008.03.003

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: The objectives of the study was to determine whether salivary progesterone (P) or estriol (E3) concentration at 16-20 weeks' gestation predicts preterm birth or the response to 17 alpha-hydroxyprogesterone caproate (17OHPC) and whether 17OHPC treatment affected the trajectory of salivary P and E3 as pregnancy progressed. STUDY DESIGN: This was a secondary analysis of a clinical trial of 17OHPC to prevent preterm birth. Baseline saliva was assayed for P and E3. Weekly salivary samples were obtained from 40 women who received 17OHPC and 40 who received placebo in a multicenter randomized trial of 17OHPC to prevent recurrent preterm delivery. RESULTS: Both low and high baseline saliva P and E3 were associated with a slightly increased risk of preterm birth. However, 17OHPC prevented preterm birth comparably, regardless of baseline salivary hormone concentrations. 17OHPC did not alter the trajectory of salivary P over pregnancy, but it significantly blunted the rise in salivary E3 as well as the rise in the E3/P ratio. CONCLUSION: 17OHPC flattened the trajectory of E3 in the second half of pregnancy, suggesting that the drug influences the fetoplacental unit.

引用

页码：506.e1 / 506.e7

页数：7

共 28 条

[1] SOURCE AND REGULATION OF 17-ALPHA-HYDROXYPROGESTERONE DURING BABOON PREGNANCY [J].