Signal transduction - Molecular ticket to enter cells

被引：34

作者：

Oved, S ^{[1
]}

Yarden, Y ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Regulat Biol, IL-76100 Rehovot, Israel

来源：

NATURE | 2002年 / 416卷 / 6877期

关键词：

D O I：

10.1038/416133a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Just as important as starting cellular signalling pathways is switching them off again. It seems that the Cbl protein has a dual function in accelerating the degradation of certain signalling molecules.

引用

页码：133 / 136

页数：3

共 8 条

[1] Generation of high curvature membranes mediated by direct endophilin bilayer interactions [J].

Farsad, K ;

Ringstad, N ;

Takei, K ;

Floyd, SR ;

Rose, K ;

De Camilli, P .

JOURNAL OF CELL BIOLOGY, 2001, 155 (02) :193-200

[2] Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis [J].

Hicke, L ;

Riezman, H .

CELL, 1996, 84 (02) :277-287

[3] The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met [J].

Petrelli, A ;

Gilestro, GF ;

Lanzardo, S ;

Comoglio, PM ;

Migone, N ;

Giordano, S .

NATURE, 2002, 416 (6877) :187-190

[4] Endophilin/SH3p4 is required for the transition from early to late stages in clathrin-mediated synaptic vesicle endocytosis [J].

Ringstad, N ;

Gad, H ;

Löw, P ;

Di Paolo, G ;

Brodin, L ;

Shupliakov, O ;

De Camilli, P .

NEURON, 1999, 24 (01) :143-154

[5] Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid [J].

Schmidt, A ;

Wolde, M ;

Thiele, C ;

Fest, W ;

Kratzin, H ;

Podtelejnikov, AV ;

Witke, W ;

Huttner, WB ;

Söling, HD .

NATURE, 1999, 401 (6749) :133-141

[6] Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors [J].

Soubeyran, P ;

Kowanetz, K ;

Szymkiewicz, I ;

Langdon, WY ;

Dikic, I .

NATURE, 2002, 416 (6877) :183-187

[7] Cbl: Many adaptations to regulate protein tyrosine kinases [J].

Thien, CBF ;

Langdon, WY .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (04) :294-305

[8] SIMILARITY OF SLI-1, A REGULATOR OF VULVAR DEVELOPMENT IN C-ELEGANS, TO THE MAMMALIAN PROTOONCOGENE C-CBL [J].

YOON, CH ;

LEE, JH ;

JONGEWARD, GD ;

STERNBERG, PW .

SCIENCE, 1995, 269 (5227) :1102-1105

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