Genetic alterations in endometrial hyperplasia and cancer

被引：17

作者：

Fabjani, G

Kucera, E

Schuster, E

Minai-Pour, M

Czerwenka, K

Sliutz, G

Leodoltera, S

Reiner, A

Zeillinger, R

机构：

[1] Univ Vienna, Sch Med, Dept Gynecol & Obstet, A-1090 Vienna, Austria

[2] Dept Pathol, A-1220 Vienna, Austria

[3] Univ Vienna, Dept Clin Pathol, A-1090 Vienna, Austria

[4] Ludwig Boltzmann Inst Gynecol Oncol & Reprod Med, A-1090 Vienna, Austria

来源：

CANCER LETTERS | 2002年 / 175卷 / 02期

关键词：

endometrial hyperplasia; endometrial cancer; microsatellite markers; loss of heterozygosity; polymerase chain reaction;

D O I：

10.1016/S0304-3835(01)00714-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Putative precursors of endometrial cancer such as complex endometrial hyperplasia with atypia have been described to be monoclonal and considered to be genetically related. In order to identify a genetic marker that could serve as a putative predictor of endometrial cancer we analyzed 14 endometrial hyperplasia and 29 endometrial cancer samples for instabilities and loss of heterozygosity (LOH) in microsatellite sequences. Deletions on the short arm of chromosome 8 were frequently detected in both endometrial hyperplasia and cancer samples, suggesting that these deletions are early events in the development of endometrial cancer. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：205 / 211

页数：7

共 33 条

[1]

Amari M, 1999, ONCOL REP, V6, P1277

[2]

Frequent deletion of chromosome 1p sequences in an aggressive histologic subtype of endometrial cancer [J].

Arlt, MF ;

Herzog, TJ ;

Mutch, DG ;

Gersell, DJ ;

Liu, H ;

Goodfellow, PJ .

HUMAN MOLECULAR GENETICS, 1996, 5 (07) :1017-1021

[3]

ENOMOTO T, 1991, CANCER RES, V51, P5308

[4]

ENOMOTO T, 1993, CANCER RES, V53, P1883

[5]

hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis [J].

Esteller, M ;

Catasus, L ;

Matias-Guiu, X ;

Mutter, GL ;

Prat, J ;

Baylin, SB ;

Herman, JG .

AMERICAN JOURNAL OF PATHOLOGY, 1999, 155 (05) :1767-1772

[6]

FUJINO T, 1994, CANCER RES, V54, P4294

[7]

FUJIWARA Y, 1993, CANCER RES, V53, P1172

[8]

Jovanovic AS, 1996, CANCER RES, V56, P1917

[9]

KERANGUEVEN F, 1995, ONCOGENE, V10, P1023

[10]

Loss of heterozygosity for defined regions on chromosomes 3, 11 and 17 in carcinomas of the uterine cervix [J].

Kersemaekers, AMF ;

Hermans, J ;

Fleuren, GJ ;

van de Vijver, MJ .

BRITISH JOURNAL OF CANCER, 1998, 77 (02) :192-200

← 1 2 3 4 →