Expression of tandem P domain K+ channel, TREK-1, in the rat carotid body

被引：16

作者：

Yamamoto, Y ^{[1
]}

Taniguchi, K ^{[1
]}

机构：

[1] Iwate Univ, Fac Agr, Dept Vet Sci, Lab Vet Anat, Morioka, Iwate 0808550, Japan

来源：

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY | 2006年 / 54卷 / 04期

关键词：

2P-domain potassium channel; carotid body; membrane potential; immunocytochemistry; rat;

D O I：

10.1369/jhc.5A6755.2005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

TREK-1 is one of the important potassium channels for regulating membrane excitability. To examine the distribution of TREK-1 in the rat carotid body, we performed RTPCR for mRNA expression and in situ hybridization and immunohistochemistry for tissue distribution of TREK-1. RT-PCR detected mRNA expression of TREK-1 in the carotid body. Furthermore, in situ hybridization revealed the localization of TREK-1 mRNA in the glomus cells. TREK-1 immunoreactivity was mainly distributed in the glomus cells and nerve fibers in the carotid body. TREK-1 may modulate potassium current of glomus cells and/or afferent nerve endings in the rat carotid body.

引用

收藏

页码：467 / 472

页数：6

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