Chronobiological concepts underlying the chronotherapy of human lung cancer

被引：22

作者：

Focan, C ^{[1
]}

机构：

[1] Clin St Joseph, B-4000 Liege, Belgium

来源：

CHRONOBIOLOGY INTERNATIONAL | 2002年 / 19卷 / 01期

关键词：

cancer chronotherapy; chronobiology; cireadian rhythms; lung cancer;

D O I：

10.1081/CBI-120002601

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This article reviews the experimental and clinical data that form the basis for the chronotherapy of lung carcinoma, specifically, nonsmall cell lung cancer (NSCLC). Circadian rhythms in cell kinetics, immunological and endocrinological endpoints, and tumor markers are reviewed. Chronopharmacology and chronotolerance studies on laboratory animals and clinical observations on cancer patients involving the main drugs active in lung carcinoma have prompted prospective Phase I-III studies to evaluate the application of chronobiologic concepts in the treatment of NSCLC. Circadian rhythmicity in host tolerance (chronotolerance) to medications has been confirmed in two prospective randomized lung cancer trials; a large phase II study has established the value of chronobiologic concepts to improve the therapeutic index of advanced NSCLC. Copyright (C) 2002 by Marcel Dekker, Inc.

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收藏

页码：253 / 273

页数：21

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