Epigenetic biomarkers in prostate cancer: Current and future uses

被引：56

作者：

Chiam, Karen ^{[1
]}

Ricciardelli, Carmela ^{[2
]}

Bianco-Miotto, Tina ^{[3
]}

机构：

[1] Garvan Inst Med Res, Canc Res Program, Sydney, NSW 2010, Australia

[2] Univ Adelaide, Sch Paediat & Reprod Hlth, Res Ctr Reprod Hlth, Discipline Obstet & Gynaecol,Robinson Inst, Adelaide, SA 5005, Australia

[3] Univ Adelaide, Sch Paediat & Reprod Hlth, Res Ctr Reprod Hlth & Early Origins Hlth & Dis, Robinson Inst, Adelaide, SA 5005, Australia

来源：

CANCER LETTERS | 2014年 / 342卷 / 02期

关键词：

Prostate cancer; Epigenetics; Biomarkers; DNA methylation; Histone modifications; MicroRNAs; CPG ISLAND HYPERMETHYLATION; MODIFICATIONS PREDICT PROGNOSIS; PROMOTER METHYLATION PROFILE; DNA METHYLATION; HISTONE MODIFICATIONS; MICRORNA EXPRESSION; MESSENGER-RNA; TUMOR-MARKERS; GSTP1; HYPERMETHYLATION; BIOCHEMICAL RECURRENCE;

D O I：

10.1016/j.canlet.2012.02.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Epigenome alterations are characteristic of nearly all human malignancies and include changes in DNA methylation, histone modifications and microRNAs (miRNAs). However, what induces these epigenetic alterations in cancer is largely unknown and their mechanistic role in prostate tumorigenesis is just beginning to be evaluated. Identification of the epigenetic modifications involved in the development and progression of prostate cancer will not only identify novel therapeutic targets but also prognostic and diagnostic markers. This review will focus on the use of epigenetic modifications as biomarkers for prostate cancer. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：248 / 256

页数：9

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