Integrins in mechanotransduction

被引：510

作者：

Katsumi, A

Orr, AW

Tzima, E

Schwartz, MA ^{[1
]}

机构：

[1] Univ Virginia, Cardiovasc Res Ctr, Charlottesville, VA 22908 USA

[2] Univ Virginia, Dept Microbiol, Charlottesville, VA 22908 USA

[3] Univ Virginia, Dept Biomed Engn, Charlottesville, VA 22908 USA

[4] Univ Virginia, Mellon Prostate Canc Inst, Charlottesville, VA 22908 USA

[5] Scripps Res Inst, Dept Cell Biol, La Jolla, CA USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2004年 / 279卷 / 13期

关键词：

D O I：

10.1074/jbc.R300038200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mechanical forces are crucial to the regulation of cell and tissue morphology and function. At the cellular level, forces influence cytoskeletal organization, gene expression, proliferation, and survival. Integrin-mediated adhesions are intrinsically mechanosensitive and a large body of data implicates integrins in sensing mechanical forces. We review the relationship between integrins and mechanical forces, the role of integrins in cellular responses to stretch and fluid flow, and propose that some of these events are mechanistically related.

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收藏

页码：12001 / 12004

页数：4

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