PHMPL: a computer program for hazard estimation using a penalized likelihood method with interval-censored and left-truncated data

被引：14

作者：

Joly, P ^{[1
]}

Letenneur, L ^{[1
]}

Alioum, A ^{[1
]}

Commenges, D ^{[1
]}

机构：

[1] Univ Bordeaux 2, ISPED, F-33076 Bordeaux, France

来源：

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE | 1999年 / 60卷 / 03期

关键词：

hazard estimation; proportional hazards; penalized likelihood; truncation; interval-censoring;

D O I：

10.1016/S0169-2607(99)00018-8

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

The Cox model is the model of choice when analyzing right-censored and possibly left-truncated survival data. The present gaper proposes a program to estimate the hazard function in a proportional hazards model and also to treat more complex observation schemes involving general censored and left-truncated data. The hazard function estimator is defined non-parametrically as the function which maximizes a penalized likelihood, and the solution is approximated using splines. The smoothing parameter is chosen using approximate cross-validation. Confidence bands for the estimator are given. As an illustration, the age-specific incidence of dementia is estimated and one of its risk factors is studied. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：225 / 231

页数：7

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