Toxicity of formaldehyde and acrolein mixtures: In vitro studies using nasal epithelial cells

被引：17

作者：

Cassee, FR ^{[1
]}

Stenhuis, WH ^{[1
]}

Groten, JP ^{[1
]}

Feron, VJ ^{[1
]}

机构：

[1] TNO TOXICOL,ZEIST,NETHERLANDS

来源：

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY | 1996年 / 48卷 / 06期

关键词：

nasal toxicity; toxicity; toxicity of formaldehyde; nasal; formaldehyde toxicity; acrolein mixtures; toxicity of acrolein mixtures; nasal cytotoxicity; cytototoxicity; nose; cytotoxicity;

D O I：

10.1016/S0940-2993(96)80060-1

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

In vitro studies with human and rat nasal epithelial cells were carried out to investigate the combined toxicity of formaldehyde and acrolein and the role of aldehyde dehydrogenases in this process. These studies showed that the toxic effect of mixtures of aldehydes was additive. In addition, aldehyde dehydrogenases were inhibited by disulfiram and acrolein in S9 incubation but disulfiram did not influence the toxicity in vitro (cell culture). This study does not support the idea that aldehyde dehydrogenases play a major role in the detoxification of exogenous aldehydes.

引用

页码：481 / 483

页数：3

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