Impact of genomic damage and ageing on stem cell function

被引：161

作者：

Behrens, Axel ^{[1
,2
]}

van Deursen, Jan M. ^{[3
,4
]}

Rudolph, K. Lenhard ^{[5
,6
]}

Schumacher, Bjoern ^{[7
,8
]}

机构：

[1] Canc Res UK London Res Inst, Mammalian Genet Lab, London WC2A 3LY, England

[2] Kings Coll London, Sch Med, London SE1 1UL, England

[3] Mayo Clin, Coll Med, Dept Pediat & Adolescent Med, Rochester, MN 55905 USA

[4] Mayo Clin, Coll Med, Dept Biochem & Mol Biol, Rochester, MN 55905 USA

[5] Fritz Lipmann Inst eV, Leibniz Inst Age Res, D-07745 Jena, Germany

[6] Univ Jena, Fac Med, Res Grp Mol Aging, Jena, Germany

[7] Univ Cologne, Fac Med, Inst Genome Stabil Ageing & Dis, D-50931 Cologne, Germany

[8] Univ Cologne, Inst Genet & Syst Biol Cologne, Cologne Excellence Cluster Cellular Stress Respon, D-50674 Cologne, Germany

来源：

NATURE CELL BIOLOGY | 2014年 / 16卷 / 03期

关键词：

DNA-DAMAGE; SELF-RENEWAL; TELOMERE DYSFUNCTION; OXIDATIVE STRESS; MICE LEADS; LIFE-SPAN; ATM; CANCER; GROWTH; SENESCENCE;

D O I：

10.1038/ncb2928

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Impairment of stem cell function contributes to the progressive deterioration of tissue maintenance and repair with ageing. Evidence is mounting that age-dependent accumulation of DNA damage in both stem cells and cells that comprise the stem cell microenvironment are partly responsible for stem cell dysfunction with ageing. Here, we review the impact of the various types of DNA damage that accumulate with ageing on stem cell functionality, as well as the development of cancer. We discuss DNA-damage-induced cell intrinsic and extrinsic alterations that influence these processes, and review recent advances in understanding systemic adjustments to DNA damage and how they affect stem cells.

引用

页码：201 / 207

页数：7

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