The temporal alteration of GAD67/GAD65 ratio in the gerbil hippocampal complex following seizure

被引：39

作者：

Kang, TC

Kim, HS

Seo, MO

Choi, SY

Kwon, OS

Baek, NI

Lee, HY

Won, MH ^{[1
]}

机构：

[1] Hallym Univ, Coll Med, Dept Anat, Chunchon 200702, South Korea

[2] Hallym Univ, Coll Life Sci, Dept Genet Engn, Chunchon 200702, South Korea

[3] Kyungpook Natl Univ, Coll Nat Sci, Dept Biochem, Taegu 702701, South Korea

[4] Kyunghee Univ, Dept Life Sci, Suwon 449701, South Korea

[5] Kyunghee Univ, Plant Metab Res Ctr, Suwon 449701, South Korea

[6] Kangwon Natl Univ, Div Food & Biotechnol, Chunchon 200701, South Korea

来源：

BRAIN RESEARCH | 2001年 / 920卷 / 1-2期

关键词：

GAD65; GAD67; gerbil; hippocampus; dentate gyrus; subiculum; epilepsy;

D O I：

10.1016/S0006-8993(01)03056-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the present study, the distribution of glutamic acid decarboxylase (GAD) isoforms in the hippocampus of the Mongolian gerbil and its association with different sequelae of spontaneous seizure were investigated to identify the roles of balance of GAD isoforms in the epileptogenesis and the recovery mechanisms in these animals. The GAD67/GAD65 ratio in the hippocampus of pre-seizure seizure sensitive (SS) gerbil was similar to3.5-fold higher as compared to seizure resistant (SR) gerbil. Following seizure, this ratio shifted to the level of SR gerbils up to 12 h postical. Therefore, the mismatched GAD67/GAD65 ratio (imbalance of GAD isoform expressions) in the hippocampus of SS gerbil implies that GABAergic neurons may be highly activated in order to regulate the increased neuronal excitability. In addition, the alteration in this ratio after seizure may be the compensatory response for reduction of epileptic activity in this animal. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：159 / 169

页数：11

共 54 条

[1]

BABB TL, 1989, J NEUROSCI, V9, P2562

[2] DORMANCY OF INHIBITORY INTERNEURONS IN A MODEL OF TEMPORAL-LOBE EPILEPSY [J].