Acetylcholinesterase Inhibition Activity of Portuguese Thymus Species Essential Oils

被引：17

作者：

Dandlen, Susana A. ^{[1
]}

Miguel, Maria G. ^{[1
,2
]}

Duarte, Joao ^{[1
]}

Faleiro, Maria L. ^{[3
]}

Sousa, Maria J. ^{[4
]}

Lima, Ana S. ^{[2
]}

Figueiredo, Ana C. ^{[2
]}

Barroso, Jose G. ^{[2
]}

Pedro, Luis G. ^{[2
]}

机构：

[1] Univ Algarve, Fac Ciencias & Tecnol, DQF, P-8005139 Faro, Portugal

[2] Univ Lisbon, Fac Ciencias Lisboa, Dep Biol Vegetal, Inst Biotecnol & Bioengn,Ctr Biotecnol Vegetal, P-1749016 Lisbon, Portugal

[3] Univ Algarve, Fac Ciencias & Tecnol, Inst Biotecnol & Bioengn, Ctr Biomed Mol & Estrut, P-8005139 Faro, Portugal

[4] Escola Super Agr, Dep Biol & Biotecnol, Inst Politecn Braganca, P-5301855 Braganca, Portugal

来源：

JOURNAL OF ESSENTIAL OIL BEARING PLANTS | 2011年 / 14卷 / 02期

关键词：

Acetylcholinesterase inhibition; Thymus; Essential oils; Carvacrol; Borneol; 1,8-Cineole; CHEMICAL-COMPOSITION; ANTIOXIDANT;

D O I：

10.1080/0972060X.2011.10643914

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Thymus species are commonly known in Portugal as thyme and they are currently used as culinary herbs, as well as for ornamental, aromatizing and traditional medicinal purposes. The essential oils isolated from the Portuguese Thymus caespititius (Sect. Micantes), T. camphoratus and T. capitellatus (Sect. Thymus, Subsect. Thymastra), T. carnosus, T. zygis subsp. sylvestris and T. zygis subsp. zygis (Sect. Thymus, Subsect. Thymus) were evaluated for acetylcholinesterase inhibition capacity. A great variability in activity was detected in the assayed essential oils, even among oils isolated from a same species with different geographical origins, such as T. caespititius. T. zygis subsp. zygis essential oil showed the strongest acetylcholinesterase inhibition capacity with an IC50 = 1.1 mu g/ml.

引用

页码：140 / 150

页数：11

共 9 条

[1]

[Anonymous], 2007, European Pharmacopoeia, V6th edn

[2]

Antioxidant activity of six Portuguese thyme species essential oils [J].

Dandlen, S. Anahi ;

Lima, A. Sofia ;

Mendes, Marta D. ;

Miguel, M. Graca ;

Faleiro, M. Leonor ;

Sousa, M. Joao ;

Pedro, Luis G. ;

Barroso, Jose G. ;

Figueiredo, A. Cristina .

FLAVOUR AND FRAGRANCE JOURNAL, 2010, 25 (03) :150-155

[3]

Acetylcholinesterase Inhibitory Activity and Chemical Composition of Commercial Essential Oils [J].

Dohi, Satomi ;

Terasaki, Masanori ;

Makino, Masakazu .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2009, 57 (10) :4313-4318

[4]

Portuguese Thymbra and Thymus Species Volatiles: Chemical Composition and Biological Activities [J].

Figueiredo, A. C. ;

Barroso, J. G. ;

Pedro, L. G. ;

Salgueiro, L. ;

Miguel, M. G. ;

Faleiro, M. L. .

CURRENT PHARMACEUTICAL DESIGN, 2008, 14 (29) :3120-3140

[5]

In vitro acetylcholinesterase inhibitory properties of thymol, carvacrol and their derivatives thymoquinone and thymohydroquinone [J].

Jukic, Mila ;

Politeo, Olivera ;

Maksimovic, Milka ;

Milos, Mia ;

Milos, Mladen .

PHYTOTHERAPY RESEARCH, 2007, 21 (03) :259-261

[6]

Antioxidant and antiacetylcholinesterase activities of five plants used as Portuguese food spices [J].

Mata, A. T. ;

Proenca, C. ;

Ferreira, A. R. ;

Serralheiro, M. L. M. ;

Nogueira, J. M. F. ;

Araujo, M. E. M. .

FOOD CHEMISTRY, 2007, 103 (03) :778-786

[7]

Aromas of rosemary and lavender essential oils differentially affect cognition and mood in healthy adults [J].

Moss, M ;

Cook, J ;

Wesnes, K ;

Duckett, P .

INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2003, 113 (01) :15-38

[8]

Acetylcholinesterase inhibitory and antioxidant properties of Cyclotrichium niveum, Thymus praecox subsp caucasicus var. caucasicus, Echinacea purpurea and E. pallida [J].

Orhan, I. ;

Senol, F. S. ;

Guelpinar, A. R. ;

Kartal, M. ;

Sekeroglu, N. ;

Deveci, M. ;

Kan, Y. ;

Sener, B. .

FOOD AND CHEMICAL TOXICOLOGY, 2009, 47 (06) :1304-1310

[9]

Butyryl- and acetyl-cholinesterase inhibitory activities in essential oils of Salvia species and their constituents [J].

Savelev, SU ;

Okello, EJ ;

Perry, EK .

PHYTOTHERAPY RESEARCH, 2004, 18 (04) :315-324

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