Acetylcholinesterase Inhibition Activity of Portuguese Thymus Species Essential Oils

被引:17
作者
Dandlen, Susana A. [1 ]
Miguel, Maria G. [1 ,2 ]
Duarte, Joao [1 ]
Faleiro, Maria L. [3 ]
Sousa, Maria J. [4 ]
Lima, Ana S. [2 ]
Figueiredo, Ana C. [2 ]
Barroso, Jose G. [2 ]
Pedro, Luis G. [2 ]
机构
[1] Univ Algarve, Fac Ciencias & Tecnol, DQF, P-8005139 Faro, Portugal
[2] Univ Lisbon, Fac Ciencias Lisboa, Dep Biol Vegetal, Inst Biotecnol & Bioengn,Ctr Biotecnol Vegetal, P-1749016 Lisbon, Portugal
[3] Univ Algarve, Fac Ciencias & Tecnol, Inst Biotecnol & Bioengn, Ctr Biomed Mol & Estrut, P-8005139 Faro, Portugal
[4] Escola Super Agr, Dep Biol & Biotecnol, Inst Politecn Braganca, P-5301855 Braganca, Portugal
关键词
Acetylcholinesterase inhibition; Thymus; Essential oils; Carvacrol; Borneol; 1,8-Cineole; CHEMICAL-COMPOSITION; ANTIOXIDANT;
D O I
10.1080/0972060X.2011.10643914
中图分类号
Q94 [植物学];
学科分类号
071001 [植物学];
摘要
Thymus species are commonly known in Portugal as thyme and they are currently used as culinary herbs, as well as for ornamental, aromatizing and traditional medicinal purposes. The essential oils isolated from the Portuguese Thymus caespititius (Sect. Micantes), T. camphoratus and T. capitellatus (Sect. Thymus, Subsect. Thymastra), T. carnosus, T. zygis subsp. sylvestris and T. zygis subsp. zygis (Sect. Thymus, Subsect. Thymus) were evaluated for acetylcholinesterase inhibition capacity. A great variability in activity was detected in the assayed essential oils, even among oils isolated from a same species with different geographical origins, such as T. caespititius. T. zygis subsp. zygis essential oil showed the strongest acetylcholinesterase inhibition capacity with an IC50 = 1.1 mu g/ml.
引用
收藏
页码:140 / 150
页数:11
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