Galectin-10, a Potential Biomarker of Eosinophilic Airway Inflammation

被引：52

作者：

Chua, Justin C. ^{[1
,2
]}

Douglass, Jo A. ^{[1
,2
]}

Gillman, Andrew ^{[1
,2
]}

O'Hehir, Robyn E. ^{[1
,2
]}

Meeusen, Els N. ^{[3
]}

机构：

[1] Alfred Hosp, Dept Allergy Immunol & Resp Med, Melbourne, Vic, Australia

[2] Monash Univ, Melbourne, Vic 3004, Australia

[3] Monash Univ, Biotechnol Res Labs, Sch Biomed Sci, Clayton, Vic, Australia

来源：

PLOS ONE | 2012年 / 7卷 / 08期

基金：

澳大利亚研究理事会;

关键词：

LEYDEN CRYSTAL PROTEIN; EXHALED NITRIC-OXIDE; ALLERGIC RHINITIS; INDUCED SPUTUM; ASTHMA; HYPERRESPONSIVENESS; EXACERBATIONS; SUBTYPES; DISEASE; COUNTS;

D O I：

10.1371/journal.pone.0042549

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Measurement of eosinophilic airway inflammation can assist in the diagnosis of allergic asthma and in the management of exacerbations, however its clinical implementation remains difficult. Galectin-10 has been associated with eosinophilic inflammation and has the potential to be used as a surrogate biomarker. This study aimed to assess the relationship between galectin-10 in sputum with sputum eosinophil counts, the current gold standard of eosinophil inflammation in the lung. Thirty-eight sputum samples were processed for both eosinophil counts by cytospins and semi-quantitative measurements of galectin-10 by western blots. A strong association was observed between galectin-10 levels in sputum and sputum eosinophil measurements, and they accurately determined sputum eosinophilia. The results support the potential for galectin-10 to be used as a surrogate biomarker of eosinophilic airway inflammation.

引用

页数：6

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