Psoriasis is associated with increased intima-media thickness-The Study of Health in Pomerania (SHIP)

被引：39

作者：

Troitzsch, Paulina ^{[1
]}

Markus, Marcello Ricardo Paulista

Doerr, Marcus ^{[2
]}

Felix, Stephan B. ^{[2
]}

Juenger, Michael ^{[3
]}

Schminke, Ulf ^{[4
]}

Schmidt, Carsten-Oliver

Voelzke, Henry

Baumeister, Sebastian E.

Arnold, Andreas ^{[3
]}

机构：

[1] Univ Med Greifswald, Inst Community Med, Dept SHIP Study Hlth Pomerania Clin Epidemiol Res, D-17475 Greifswald, Germany

[2] Univ Med Greifswald, Dept Internal Med B, D-17475 Greifswald, Germany

[3] Univ Med Greifswald, Clin & Policlin Dermatol, D-17475 Greifswald, Germany

[4] Univ Med Greifswald, Clin & Policlin Neurol, D-17475 Greifswald, Germany

来源：

ATHEROSCLEROSIS | 2012年 / 225卷 / 02期

关键词：

Psoriasis; Plaque; Atherosclerosis; Risk factors; Population-based study; Epidemiology; ENDOTHELIAL GROWTH-FACTOR; CAROTID-ARTERY INTIMA; MYOCARDIAL-INFARCTION; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; RISK-FACTOR; ATHEROSCLEROSIS; COHORT; PLAQUE; MECHANISMS;

D O I：

10.1016/j.atherosclerosis.2012.09.026

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Psoriasis has been associated with cardiovascular diseases, but its relationship to markers of subclinical atherosclerosis has not been fully elucidated. The aim of the study is to analyze the association of psoriasis with common carotid artery intima+media thickness (CCA-IMT) and plaque prevalence of the carotid arteries. Methods: Data of 1987 men and women aged 25-88 years from the population-based Study of Health in Pomerania (SHIP) in north-eastern Germany were used. Cross-sectional associations of psoriasis with IMT and carotid plaque prevalence were analyzed using linear and logistic regression models adjusted for relevant confounders (age, sex, smoking, alcohol consumption, waist circumference, physical activity, systolic blood pressure, anti-hypertensive medication, acetylsalicylic acid, HbA(1c), total/HDL cholesterol ratio, lipid-lowering medication). Results: Psoriasis was associated with mean CCA-IMT, but not with carotid plaque prevalence. Comparisons between subjects with and without psoriasis showed an adjusted mean difference of the CCA-IMT of 0.016 mm (95% confidence interval [CI]: 0.004 mm-0.028 mm, p < 0.01) and an odds ratio for plaque prevalence of 1.12 (95% CI: 0.85-1.47) after adjusting for confounders. Conclusion: Our findings suggest that psoriasis is associated with increased carotid mean IMT and might therefore contribute to the atherosclerotic process and subsequent cardiovascular events. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：486 / 490

页数：5

共 33 条

[1] Augustin M, ACTA DERM VENEREOL, V90, P147
[2] The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-γ, interleukin-2, and tumor necrosis factor-α, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations:: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients
Austin, LM
Ozawa, M
Kikuchi, T
Walters, IB
Krueger, JG
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1999, 113 (05) : 752 - 759
[3] Increased carotid artery intima-media thickness and impaired endothelial function in psoriasis
Balci, D. D.
Balci, A.
Karazincir, S.
Ucar, E.
Iyigun, U.
Yalcin, F.
Seyfeli, E.
Inandi, T.
Egilmez, E.
[J]. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2009, 23 (01) : 1 - 6
[4] VEGF-A, VEGF-D and VEGF-DΔNΔC induced intimal hyperplasia in carotid arteries
Bhardwaj, S
Roy, H
Heikura, T
Ylä-Herttuala, S
[J]. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2005, 35 (11) : 669 - 676
[5] Levels of endothelial cell stimulating angiogenesis factor and vascular endothelial growth factor are elevated in psoriasis
Bhushan, M
McLaughlin, B
Weiss, JB
Griffiths, CEM
[J]. BRITISH JOURNAL OF DERMATOLOGY, 1999, 141 (06) : 1054 - 1060
[6] Bis JC, NAT GENET, V43, P940
[7] Psoriasis and risk of incident myocardial infarction, stroke or transient ischaemic attack: an inception cohort study with a nested case-control analysis
Brauchli, Y. B.
Jick, S. S.
Miret, M.
Meier, C. R.
[J]. BRITISH JOURNAL OF DERMATOLOGY, 2009, 160 (05) : 1048 - 1056
[8] Association between psoriasis and the metabolic syndrome
Cohen, A. D.
Sherf, M.
Vidavsky, L.
Vardy, D. A.
Shapiro, J.
Meyerovitch, J.
[J]. DERMATOLOGY, 2008, 216 (02) : 152 - 155
[9] C-reactive protein and leucocyte activation in psoriasis vulgaris according to severity and therapy
Coimbra, S.
Oliveira, H.
Reis, F.
Belo, L.
Rocha, S.
Quintanilha, A.
Figueiredo, A.
Teixeira, F.
Castro, E.
Rocha-Pereira, P.
Santos-Silva, A.
[J]. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2010, 24 (07) : 789 - 796
[10] Dose-response analyses using restricted cubic spline functions in public health research
Desquilbet, Loic
Mariotti, Francois
[J]. STATISTICS IN MEDICINE, 2010, 29 (09) : 1037 - 1057

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