Antibody-induced neutrophil activation as a trigger for transfusion-related acute lung injury in an ex vivo rat lung model

被引:123
作者
Sachs, UJH
Hattar, K
Weissmann, N
Bohle, RM
Weiss, T
Sibelius, U
Bux, J
机构
[1] Univ Giessen, Inst Clin Immunol & Transfus Med, D-35392 Giessen, Germany
[2] Univ Giessen, Dept Internal Med, D-35392 Giessen, Germany
[3] Univ Giessen, Dept Pathol, D-35392 Giessen, Germany
[4] German Red Cross Blood Serv W, Hagen, Germany
[5] Rudolf Virchow Ctr Expt Biomed, Wurzburg, Germany
关键词
D O I
10.1182/blood-2005-04-1744
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Transfusion-related acute lung injury (TRALI) is a hazardous complication of transfusion and has become the leading cause of transfusion-related death in the United States and United Kingdom. Although leukoagglutinating antibodies have been frequently shown to be associated with the syndrome, the mechanism by which they induce TRALI is poorly understood. Therefore, we reproduced TRALI in an ex vivo rat lung model. Our data demonstrate that TRALI induction by antileukocyte antibodies is dependent on the density of the cognate antigen but does not necessarily require leukoagglutinating properties of the antibody or the presence of complement proteins. Rather, antibody-mediated activation of neutrophils seems to initiate TRALI, a process that could be triggered by neutrophil stimulation with fMLP Antibody-mediated neutrophil activation and subsequent release of reactive oxygen species may thus represent key events in the pathophysiologic cascade that leads to immune TRALI.
引用
收藏
页码:1217 / 1219
页数:3
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