A top-notch dilemma: The complex role of NOTCH signaling in osteoarthritis

被引：12

作者：

Ratneswaran, Anusha ^{[1
]}

Beier, Frank ^{[1
]}

机构：

[1] Univ Western Ontario, Dept Physiol & Pharmacol, Schulich Sch Med & Dent, London, ON N6A 5C1, Canada

来源：

SCIENCE SIGNALING | 2015年 / 8卷 / 386期

基金：

加拿大健康研究院;

关键词：

CARTILAGE;

D O I：

10.1126/scisignal.aac7862

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A study by Liu et al. in the current issue of Science Signaling explores the complex dual role of NOTCH in the etiology of osteoarthritis by comparing gain-of-function mouse models representing aberrant pathological signaling and transient physiological signaling.

引用

页数：2

共 12 条

[1]

Appleton C. T. G., 2015, ARTHRITIS RHEUM

[2]

Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development [J].

Hosaka, Yoko ;

Saito, Taku ;

Sugita, Shurei ;

Hikata, Tomohiro ;

Kobayashi, Hiroshi ;

Fukai, Atsushi ;

Taniguchi, Yuki ;

Hirata, Makoto ;

Akiyama, Haruhiko ;

Chung, Ung-il ;

Kawaguchi, Hiroshi .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (05) :1875-1880

[3]

Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development [J].

Kohn, Anat ;

Dong, Yufeng ;

Mirando, Anthony J. ;

Jesse, Alana M. ;

Honjo, Tasuku ;

Zuscik, Michael J. ;

O'Keefe, Regis J. ;

Hilton, Matthew J. .

DEVELOPMENT, 2012, 139 (06) :1198-1212

[4]

Liu Z., 2015, SCI SIGNAL, V8, pra71

[5]

RBP-Jκ-Dependent Notch Signaling Is Required for Murine Articular Cartilage and Joint Maintenance [J].

Mirando, Anthony J. ;

Liu, Zhaoyang ;

Moore, Tyler ;

Lang, Alexandra ;

Kohn, Anat ;

Osinski, Alana M. ;

O'Keefe, Regis J. ;

Mooney, Robert A. ;

Zuscik, Michael J. ;

Hilton, Matthew J. .

ARTHRITIS AND RHEUMATISM, 2013, 65 (10) :2623-2633

[6]

Osteoarthritis Year in Review 2014: mechanics - basic and clinical studies in osteoarthritis [J].

Moyer, R. F. ;

Ratneswaran, A. ;

Beier, F. ;

Birmingham, T. B. .

OSTEOARTHRITIS AND CARTILAGE, 2014, 22 (12) :1989-2002

[7]

Notch signaling is involved in human articular chondrocytes de-differentiation during osteoarthritis [J].

Sassi, Nadia ;

Gadgadi, Nadia ;

Laadhar, Lilia ;

Allouche, Mohamed ;

Mourali, Slim ;

Zandieh-Doulabi, Behrouz ;

Hamdoun, Moncef ;

Nulend, Jenneke Klein ;

Makni, Sondes ;

Sellami, Slaheddine .

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2014, 34 (01) :48-57

[8]

Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2 [J].

Sugita, Shurei ;

Hosaka, Yoko ;

Okada, Keita ;

Mori, Daisuke ;

Yano, Fumiko ;

Kobayashi, Hiroshi ;

Taniguchi, Yuki ;

Mori, Yoshifumi ;

Okuma, Tomotake ;

Chang, Song Ho ;

Kawata, Manabu ;

Taketomi, Shuji ;

Chikuda, Hirotaka ;

Akiyama, Haruhiko ;

Kageyama, Ryoichiro ;

Chung, Ung-il ;

Tanaka, Sakae ;

Kawaguchi, Hiroshi ;

Ohba, Shinsuke ;

Saito, Taku .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (10) :3080-3085

[9]

Interleukin 6 mediates selected effects of Notch in chondrocytes [J].

Zanotti, S. ;

Canalis, E. .

OSTEOARTHRITIS AND CARTILAGE, 2013, 21 (11) :1766-1773

[10]

Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model [J].

Zhang, Xianrong ;

Zhu, Ji ;

Liu, Fei ;

Li, Yumei ;

Chandra, Abhishek ;

Levin, L. Scott ;

Beier, Frank ;

Enomoto-Iwamoto, Motomi ;

Qin, Ling .

BONE RESEARCH, 2014, 2

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