Sem1 A versatile "molecular glue"?

被引：12

作者：

Faza, Marius Boulos ^{[1
,2
]}

Kemmler, Stefan ^{[1
]}

Panse, Vikram Govind ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Inst Biochem IBC, Zurich, Switzerland

[2] Life Sci Zurich, MLS Program, Zurich, Switzerland

来源：

NUCLEUS | 2010年 / 1卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

Sem1; Dss1; TREX-2; mRNA export; gene gating; proteasome; COP9; BRCA2; genome instability; MESSENGER-RNA EXPORT; NUCLEAR-PORE ASSOCIATION; FUNCTIONAL COMPONENT; COMPLEX; DSS1; PROTEASOME; YEAST; PROTEIN; TRANSCRIPTION; STABILITY;

D O I：

10.4161/nucl.1.1.10424

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The evolutionary conserved protein Sem1/Dss1 is a bona fide subunit of the regulatory particle (RP) of the proteasome and in mammalian cells stabilizes the tumor suppressor protein BRCA2. A recent study from our laboratory has revealed an unexpected non-proteasomal role of Sem1 in mRNA export. We found that Sem1, independent of the RP, is a functional component of the nuclear pore associated TREX-2 complex that is directly involved in the dynamic re-localization of a subset of DNA loci to the nuclear periphery. Like other components of TREX-2, Sem1 is required for proper nuclear export of mRNAs, transcription elongation and preventing transcription-associated genomic instability. Strikingly, Sem1 associates with a third multi-subunit protein complex namely the COP9 signalosome, which is involved in de-neddylation. We propose that Sem1 is a versatile protein that regulates the functional integrity of multiple protein complexes involved in diverse biological pathways.

引用

页码：12 / 17

页数：6

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