Inflammation, metaflammation and immunometabolic disorders

被引：1910

作者：

Hotamisligil, Gokhan S. ^{[1
,2
]}

机构：

[1] Broad Inst Harvard & MIT, Harvard TH Chan Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA

[2] Broad Inst Harvard & MIT, Harvard TH Chan Sch Publ Hlth, Sabri Ulker Ctr, Boston, MA 02115 USA

来源：

NATURE | 2017年 / 542卷 / 7640期

基金：

美国国家卫生研究院;

关键词：

INDUCED INSULIN-RESISTANCE; ENDOPLASMIC-RETICULUM STRESS; ADIPOSE-TISSUE INFLAMMATION; NECROSIS-FACTOR-ALPHA; DIET-INDUCED OBESITY; REGULATORY T-CELLS; SKELETAL-MUSCLE; METABOLIC DYSFUNCTION; FATTY-ACIDS; ER STRESS;

D O I：

10.1038/nature21363

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Proper regulation and management of energy, substrate diversity and quantity, as well as macromolecular synthesis and breakdown processes, are fundamental to cellular and organismal survival and are paramount to health. Cellular and multicellular organization are defended by the immune response, a robust and critical system through which self is distinguished from non-self, pathogenic signals are recognized and eliminated, and tissue homeostasis is safeguarded. Many layers of evolutionarily conserved interactions occur between immune response and metabolism. Proper maintenance of this delicate balance is crucial for health and has important implications for many pathological states such as obesity, diabetes, and other chronic non-communicable diseases.

引用

页码：177 / 185

页数：9

共 140 条

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The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response [J].