The Id proteins and angiogenesis

被引：184

作者：

Benezra, R

Rafii, S

Lyden, D

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Cell Biol, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Pediat, New York, NY 10021 USA

[3] Cornell Univ, Coll Med, Dept Hematol Oncol, New York, NY 10021 USA

来源：

ONCOGENE | 2001年 / 20卷 / 58期

关键词：

Id; angiogenesis; endothelial; precursor;

D O I：

10.1038/sj.onc.1205160

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since the identification of the Id proteins over a decade ago, a great many cell cycle and cell fate decisions have been shown to be under the control of these proteins as described in other sections of this review issue. Perhaps the most unsuspected activity of this class of proteins has been their essential role in angiogenesis, both in the forebrain during development and during the growth and metastasis of tumors in adults. This section of the review issue will focus on the key observations which have led to these conclusions, speculations about potential mechanisms and the outlook for potential therapeutic interventions.

引用

收藏

页码：8334 / 8341

页数：8

相关论文

共 76 条

[1] Isolation of putative progenitor endothelial cells for angiogenesis [J].

Asahara, T ;

Murohara, T ;

Sullivan, A ;

Silver, M ;

vanderZee, R ;

Li, T ;

Witzenbichler, B ;

Schatteman, G ;

Isner, JM .

SCIENCE, 1997, 275 (5302) :964-967

[2] Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all αv integrins [J].

Bader, BL ;

Rayburn, H ;

Crowley, D ;

Hynes, RO .

CELL, 1998, 95 (04) :507-519

[3] Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1 [J].

Barleon, B ;

Sozzani, S ;

Zhou, D ;

Weich, HA ;

Mantovani, A ;

Marme, D .

BLOOD, 1996, 87 (08) :3336-3343

[4] THE PROTEIN ID - A NEGATIVE REGULATOR OF HELIX-LOOP-HELIX DNA-BINDING PROTEINS [J].

BENEZRA, R ;

DAVIS, RL ;

LOCKSHON, D ;

TURNER, DL ;

WEINTRAUB, H .

CELL, 1990, 61 (01) :49-59

[5] Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal [J].

Benjamin, LE ;

Keshet, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (16) :8761-8766

[6] Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal [J].

Benjamin, LE ;

Golijanin, D ;

Itin, A ;

Pode, D ;

Keshet, E .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (02) :159-165

[7] Effects of angiogenesis inhibitors on multistage carcinogenesis in mice [J].

Bergers, G ;

Javaherian, K ;

Lo, KM ;

Folkman, J ;

Hanahan, D .

SCIENCE, 1999, 284 (5415) :808-812

[8] The role of vascular endothelial growth factor in blood vessel formation [J].

Breier, G ;

Risau, W .

TRENDS IN CELL BIOLOGY, 1996, 6 (12) :454-456

[9] Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression [J].

Brogi, E ;

Schatteman, G ;

Wu, T ;

Kim, EA ;

Varticovski, L ;

Keyt, B ;

Isner, JM .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (02) :469-476

[10] INTEGRIN ALPHA(V)BETA(3) ANTAGONISTS PROMOTE TUMOR-REGRESSION BY INDUCING APOPTOSIS OF ANGIOGENIC BLOOD-VESSELS [J].

BROOKS, PC ;

MONTGOMERY, AMP ;

ROSENFELD, M ;

REISFELD, RA ;

HU, TH ;

KLIER, G ;

CHERESH, DA .

CELL, 1994, 79 (07) :1157-1164

← 1 2 3 4 5 6 7 8 →