Effect of caffeine on leg muscle pain during cycling exercise among females

Purpose: This double-blind, within-subjects experiment examined the effects of ingesting two doses of caffeine on perceptions of leg muscle pain during moderate-intensity cycling exercise among females. Methods: Low-caffeine-consuming college-aged females (N = 11) ingested one of two doses of caffeine (5 or 10 mg center dot kg(-1) body weight) or a placebo and 1 h later completed 30 min of cycling on an ergometer at approximately 60% (V)over dotO(2peak). The conditions were completed in a counterbalanced order. Perceptions of leg muscle pain as well as power output, heart rate, systolic blood pressure, and oxygen consumption ((V)over dotO(2)) were recorded during exercise. Results: Caffeine had a significant effect on leg muscle pain ratings [F (2,20) = 10.63, P = 0.001, eta(2) = 0.52]. The mean pain intensity scores during exercise after ingesting 10 mg center dot kg(-1) body weight caffeine, 5 mg center dot kg(-1) body weight caffeine, and placebo were 1.6 1.1, 1.3 0.7, and 2.4 1.1, respectively. Conclusion: The results support that caffeine ingestion has a large effect on reducing leg muscle pain during exercise among females, but this effect does not appear to be dose-dependent between 5 and 10 mg center dot kg(-1) body weight caffeine.