A Novel and Convenient Protocol for Synthesis of Pyridazines

被引：52

作者：

Attanasi, Orazio A. ^{[1
]}

Favi, Gianfranco ^{[1
]}

Filippone, Paolino ^{[1
]}

Perrulli, Francesca R. ^{[1
]}

Santeusanio, Stefania ^{[1
]}

机构：

[1] Univ Urbino Carlo Bo, Ist Chim Organ, I-61029 Urbino, Italy

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 02期

关键词：

DIELS-ALDER REACTIONS; CYCLIZATION REACTIONS; GENERAL-SYNTHESIS; DERIVATIVES; GABA; AMINOPYRIDAZINES; DIHYDROCHLORIDE; CYCLOADDITION; ANTAGONIST; INHIBITORS;

D O I：

10.1021/ol802432z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new flexible strategy for the synthesis of diversely functionalized pyridazines from 4-chloro-1,2-diaza-1,3-butadienes and active methylene compounds is reported. The high chemoselectivity of this approach offers access to structural precursors of GABA-A antagonist analogues.

引用

页码：309 / 312

页数：4

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