Wound healing - A literature review

被引：735

作者：

de Oliveira Gonzalez, Ana Cristina ^{[1
,2
]}

Costa, Tila Fortuna ^{[1
,3
]}

Andrade, Zilton de Araujo ^{[1
,2
]}

Alves Peixoto Medrado, Alena Ribeiro ^{[1
,3
]}

机构：

[1] Fiocruz MS, CPqGM, Fundacao Oswaldo Cruz, Goncalo Moniz Res Ctr, Salvador, BA, Brazil

[2] Fiocruz MS, Fundacao Oswaldo Cruz, Salvador, BA, Brazil

[3] Bahiana Sch Med & Publ Hlth EBMSP, Salvador, BA, Brazil

来源：

ANAIS BRASILEIROS DE DERMATOLOGIA | 2016年 / 91卷 / 05期

关键词：

Cell proliferation; Hedgehog proteins; Inflammation; Wound Healing; LEVEL LASER THERAPY; SONIC-HEDGEHOG; MESENCHYMAL TRANSITIONS; EXTRACELLULAR-MATRIX; TISSUE-REPAIR; PERICYTES; ANGIOGENESIS; MECHANISMS; DISEASE; CELLS;

D O I：

10.1590/abd1806-4841.20164741

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

Regeneration and tissue repair processes consist of a sequence of molecular and cellular events which occur after the onset of a tissue lesion in order to restore the damaged tissue. The exsudative, proliferative, and extracellular matrix remodeling phases are sequential events that occur through the integration of dynamic processes involving soluble mediators, blood cells, and parenchymal cells. Exsudative phenomena that take place after injury contribute to the development of tissue edema. The proliferative stage seeks to reduce the area of tissue injury by contracting myofibroblasts and fibroplasia. At this stage, angiogenesis and reepithelialization processes can still be observed. Endothelial cells are able to differentiate into mesenchymal components, and this difference appears to be finely orchestrated by a set of signaling proteins that have been studied in the literature. This pathway is known as Hedgehog. The purpose of this review is to describe the various cellular and molecular aspects involved in the skin healing process.

引用

页码：614 / 620

页数：7

共 54 条

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