Changes in hippocampal and cortical B1 bradykinin receptor biological activity in two experimental models of epilepsy

被引:30
作者
Bregola, G
Varani, K
Gessi, S
Beani, L
Bianchi, C
Borea, PA
Regoli, D
Simonato, M [1 ]
机构
[1] Univ Ferrara, Dept Clin & Expt Med, Pharmacol Sect, I-44100 Ferrara, Italy
[2] Univ Ferrara, Ctr Biotechnol, I-44100 Ferrara, Italy
关键词
epilepsy; kindling; kainate; bradykinin; glutamate release;
D O I
10.1016/S0306-4522(99)00075-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
An increased response to the activation of receptors mediating excitatory effects may be involved in some forms of epilepsy. In this study, it has been tested whether B-1 bradykinin receptors (which mediate excitatory effects in the peripheral nervous system and have little constitutional expression in the central nervous system) may be proposed in this role. Two experimental models of epilepsy (kindling and kainate) have been employed, and glutamate outflow experiments have been performed in hippocampal and cortical slices taken from control, kindled and kainate-treated rats. The endogenous B-1 receptor agonist Lys-des-Arg(9)-bradykinin (10(-7) M) did not affect electrically-evoked glutamate overflow in control animals, but concentration-dependently increased it in kindled rats (maximal effect +40 to +50%) and, to a lesser extent ( + 20%), in kainate-treated rats. These effects were fully prevented by the selective B-1 receptor antagonist R-715 (10(-6) M), but not by the selective B-2 receptor antagonist Hoe 140 (10(-6) M). The observed changes in B-1 bradykinin receptor biological activity may play a role in epileptic hyperexcitability. (C) 1999 IBRO. Published by Elsevier Science Ltd.
引用
收藏
页码:1043 / 1049
页数:7
相关论文
共 40 条
  • [1] TRANSMITTER RELEASE IN HIPPOCAMPAL SLICES FROM RATS WITH LIMBIC SEIZURES PRODUCED BY SYSTEMIC ADMINISTRATION OF KAINIC ACID
    ARIAS, C
    MONTIEL, T
    TAPIA, R
    [J]. NEUROCHEMICAL RESEARCH, 1990, 15 (06) : 641 - 645
  • [2] Changes in hippocampal circuitry after pilocarpine-induced seizures as revealed by opioid receptor distribution and activation
    Bausch, SB
    Chavkin, C
    [J]. JOURNAL OF NEUROSCIENCE, 1997, 17 (01) : 477 - 492
  • [3] BHOOLA KD, 1992, PHARMACOL REV, V44, P1
  • [4] EXCITATORY AMINO-ACID RECEPTORS IN EPILEPSY
    DINGLEDINE, R
    MCBAIN, CJ
    MCNAMARA, JO
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (08) : 334 - 338
  • [5] Inducible receptors
    Donaldson, LF
    Hanley, MR
    Villablanca, AC
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1997, 18 (05) : 171 - 181
  • [6] DRAPEAU G, 1988, METHOD ENZYMOL, V163, P263
  • [7] ANIMAL-MODELS OF THE EPILEPSIES
    FISHER, RS
    [J]. BRAIN RESEARCH REVIEWS, 1989, 14 (03) : 245 - 278
  • [8] Interleukin-1 alpha in the brain is induced by audiogenic seizure
    Gahring, LC
    White, HS
    Skradski, SL
    Carlson, NG
    Rogers, SW
    [J]. NEUROBIOLOGY OF DISEASE, 1997, 3 (04) : 263 - 269
  • [9] GALL C, 1990, PROG BRAIN RES, V83, P371
  • [10] LONG-TERM ENHANCEMENT OF K+-EVOKED RELEASE OF L-GLUTAMATE IN ENTORHINAL KINDLED RATS
    GEULA, C
    JARVIE, PA
    LOGAN, TC
    SLEVIN, JT
    [J]. BRAIN RESEARCH, 1988, 442 (02) : 368 - 372