Osteoimmunology - The hidden immune regulation of bone

被引：114

作者：

Caetano-Lopes, J. ^{[1
]}

Canhao, H. ^{[1
,2
]}

Fonseca, J. E. ^{[1
,2
]}

机构：

[1] Univ Lisbon, Rheumatol Res Unit, Inst Mol Med, Fac Med, P-1649028 Lisbon, Portugal

[2] Hosp Santa Maria, Rheumatol & Metab Bone Dis Dept, Lisbon, Portugal

来源：

AUTOIMMUNITY REVIEWS | 2009年 / 8卷 / 03期

关键词：

Osteoimmunology; Osteoimmunoendocrinology; Bone; Immune system; Adipose tissue; PPAR-GAMMA; MOLECULAR-MECHANISMS; T-CELLS; METABOLISM; DIFFERENTIATION; INFLAMMATION; INHIBIT; INNATE; LEPTIN; OSTEOCLASTOGENESIS;

D O I：

10.1016/j.autrev.2008.07.038

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Osteoimmunology is an emerging field of research dedicated to the investigation of the interactions between the immune and skeletal systems. These interactions are not only mediated by the release of cytokines and chemokines but also by direct cell-cell contact. Recently, it was proposed that immunoreceptors found in the immune cells are also an essential signal for osteoclasts activation, along with receptor activator NF-kappa B (RANK) ligand (RANKL) and macrophage-colony stimulating factor (M-CSF). In addition, adipose tissue also produces several factors (adipokines) that are known to interfere with the immune system and bone homeostasis. Chronic inflammation strongly influences osteoimmunology determining profound metabolic, structural and functional changes in bone. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：250 / 255

页数：6

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