Antibodies to N-methyl-D-aspartate glutamate receptors in Creutzfeldt-Jakob disease patients

被引：35

作者：

Fujita, Koji ^{[1
]}

Yuasa, Tatsuhiko ^{[2
]}

Takahashi, Yukitoshi ^{[3
]}

Tanaka, Keiko ^{[4
]}

Sako, Wataru ^{[1
]}

Koizumi, Hidetaka ^{[1
,5
]}

Iwasaki, Yasushi ^{[6
]}

Yoshida, Mari ^{[6
]}

Izumi, Yuishin ^{[1
]}

Kaji, Ryuji ^{[1
]}

机构：

[1] Univ Tokushima, Grad Sch, Dept Clin Neurosci, Tokushima 7708503, Japan

[2] Kamagaya Gen Hosp, Dept Neurol, Kamagaya Chiba Med Ctr Intractable Neurol Dis, Kamagaya 2730121, Japan

[3] Shizuoka Inst Epilepsy & Neurol Disorders, Natl Epilepsy Ctr, Aoi Ku, Shizuoka 4208688, Japan

[4] Kanazawa Med Univ, Dept Neurol, Kahoku, Ishikawa 9200293, Japan

[5] Kyoto Prefectural Univ Med, Dept Neurol, Kyoto 6020841, Japan

[6] Aichi Med Univ, Inst Med Sci Aging, Dept Neuropathol, Nagakute, Aichi 4801195, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2012年 / 251卷 / 1-2期

关键词：

Creutzfeldt-Jakob disease; N-methyl-D-aspartate glutamate receptors; Autoantibodies; AUTOANTIBODIES; MURINE; KURU;

D O I：

10.1016/j.jneuroim.2012.06.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Psychiatric symptom can be a prominent feature early in Creutzfeldt-Jakob disease (CJD), which is also common in autoantibody-mediated limbic encephalitis. We hypothesized that anti-neuronal autoantibodies, especially those against N-methyl-D-aspartate glutamate receptors (NMDAR), can also be associated with CJD. Thirteen patients with CJD and 13 patients with limbic encephalitis were enrolled. Immunohistochemistry demonstrated that serum of CJD patients reacted with neuronal components of the rat hippocampus, indicating that those samples contained anti-neuronal antibodies. Enzyme-linked immunosorbent assay revealed that titers of antibodies against peptides of GluN2B subunit of NMDAR were significantly elevated in the serum and cerebrospinal fluid of CJD patients. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：90 / 93

页数：4

共 15 条

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