The Role of FXR in Disorders of Bile Acid Homeostasis

被引：88

作者：

Eloranta, Jyrki J. ^{[1
]}

Kullak-Ublick, Gerd A. ^{[1
]}

机构：

[1] Univ Zurich Hosp, Div Clin Pharmacol & Toxicol, CH-8091 Zurich, Switzerland

来源：

PHYSIOLOGY | 2008年 / 23卷 / 05期

基金：

瑞士国家科学基金会;

关键词：

D O I：

10.1152/physiol.00020.2008

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

As ligands for the nuclear receptor FXR, bile acids regulate their own synthesis, transport, and conjugation, thus protecting against bile acid toxicity. Recently, the role of genetic variants in FXR itself, FXR target genes, and regulators of FXR in the pathophysiology of the liver and intestine has become increasingly evident.

引用

页码：286 / 295

页数：10

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