A possible role of slips in cytochrome c oxidase in the antioxygen defense system of the cell

被引：42

作者：

Papa, S

Guerrieri, F

Capitanio, N

机构：

[1] Inst. Med. Biochem. Chem. Med. Fac., University of Bari, Policlinico, 70124 Bari, Piazza Giulio Cesare

[2] Inst. of Med. Biochem. and Chemistry, University of Bari, Bari

来源：

BIOSCIENCE REPORTS | 1997年 / 17卷 / 01期

关键词：

cytochrome c oxidase; proton pumps; reactive oxygen species; respiratory protection;

D O I：

10.1023/A:1027331116866

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evidence is available showing that the coupling efficiency of the proton pump in cytochrome c oxidase of mitochondria can under certain conditions decrease significantly below the maximum attainable value. The view is developed that slips in the proton pump of cytochrome c oxidase represent an intrinsic switch mechanism which regulates the relative contribution of energy transfer and respiratory protection against oxygen toxicity by the oxidase.

引用

页码：23 / 31

页数：9

共 33 条

[1] OXYGEN ACTIVATION AND THE CONSERVATION OF ENERGY IN CELL RESPIRATION [J].