Pentoxifylline and vitamin E combination for superficial radiation-induced fibrosis: A phase II clinical trial

被引:43
作者
Haddad, P [1 ]
Kataghchi, B [1 ]
Amouzegar-Hashemi, F [1 ]
机构
[1] Univ Tehran Med Sci, Inst Canc, Dept Radiat Oncol, Tehran, Iran
关键词
D O I
10.1016/j.radonc.2005.09.014
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We treated 34 radiation-induced superficial fibrotic lesions with pentoxifylline and vitamin E for 3 months. Mean surface area of the lesions decreased from 112 to 65 cm(2) after treatment (P < 0.001). A subgroup of 21 fibrotic lesions received the medications for 6 months, in which surface area decreased from 80 to 27 cm(2) (p < 0.001). Pentoxifylline-vitamin E combination improved radiation-induced fibrosis. (c) 2005 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 77 (2005) 324-326.
引用
收藏
页码:324 / 326
页数:3
相关论文
共 8 条
[1]   Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol [J].
Delanian, S ;
Balla-Mekias, S ;
Lefaix, JL .
JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (10) :3283-3290
[2]   The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway [J].
Delanian, S ;
Lefaix, JL .
RADIOTHERAPY AND ONCOLOGY, 2004, 73 (02) :119-131
[3]   Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis [J].
Delanian, S ;
Porcher, R ;
Balla-Mekias, S ;
Lefaix, JL .
JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (13) :2545-2550
[4]   Striking regression of radiation-induced fibrosis by a combination of pentoxifylline and tocopherol [J].
Delanian, S .
BRITISH JOURNAL OF RADIOLOGY, 1998, 71 (848) :892-894
[5]  
Fischer M, 2001, EUR J DERMATOL, V11, P38
[6]   Resolution of symptomatic epidural fibrosis following treatment with combined pentoxifylline-tocopherol [J].
Georges, C ;
Lefaix, JL ;
Delanian, S .
BRITISH JOURNAL OF RADIOLOGY, 2004, 77 (922) :885-887
[7]   Double-blind placebo-controlled randomised trial of vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer [J].
Gothard, L ;
Cornes, P ;
Earl, J ;
Hall, E ;
MacLaren, J ;
Mortimer, P ;
Peacock, J ;
Peckitt, C ;
Woods, M ;
Yarnold, J .
RADIOTHERAPY AND ONCOLOGY, 2004, 73 (02) :133-139
[8]   Striking regression of subcutaneous fibrosis induced by high doses of gamma rays using a combination of pentoxifylline and α-tocopherol:: An experimental study [J].
Lefaix, JL ;
Delanian, S ;
Vozenin, MC ;
Leplat, JJ ;
Tricaud, Y ;
Martin, M .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1999, 43 (04) :839-847