PDT light dosimetry revisited

A versatile PDT light dosimetry model is described incorporating the effects of drug photobleaching, drug elimination, and normal tissue damage. The dependence of the necrosis depth (d(n),) on the incident light dose for the four major modes of PDT light delivery has the form: d(n) = delta log(e)(DG), where S is the optical penetration depth of the tumor tissue, D is the ratio of the incident light dose to the energy fluence at the necrosis threshold, and G is a function of the tissue optical constants. Light dosimetry graphs were calculated for Photofrin(R) at standard conditions.