SR141716A, a CB1 cannabinoid receptor antagonist, potentiates the locomotor stimulant effects of amphetamine and apomorphine

被引:40
作者
Masserano, JM [1 ]
Karoum, F [1 ]
Wyatt, RJ [1 ]
机构
[1] NIMH, Neuropsychiat Branch, Bethesda, MD 20892 USA
来源
BEHAVIOURAL PHARMACOLOGY | 1999年 / 10卷 / 04期
关键词
cannabinoid; SR; 141716A; amphetamine; apomorphine; locomotor activity;
D O I
10.1097/00008877-199907000-00010
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The intraperitoneal (i.p.) injection of apomorphine or d-amphetamine significantly increased locomotor activity in Sprague-Dawley rats. Prior administration of the cannabinoid receptor antagonist, SR 141716A significantly enhanced the stimulant effect of both d-amphetamine and apomorphine in a dose-dependent manner. Administration of SR 141716A alone had no effect on locomotor activity. These data indicate that endogenous cannabinoids exert an inhibitory action on the increase in locomotor activity produced by amphetamine and apomorphine. (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码:429 / 432
页数:4
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