An improved oxadiazole synthesis using peptide coupling reagents

被引：81

作者：

Liang, GB

Feng, DD

机构：

[1] Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 37期

关键词：

D O I：

10.1016/S0040-4039(96)01492-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Substituted 1,2,4-oxadiazoles were synthesized in good yields in a one pot procedure by condensation of the corresponding amidoxime with carboxylic acids in the presence of a peptide coupling reagent in diglyme. followed by heating the reaction mixture to 100 degrees C for several hours. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：6627 / 6630

页数：4

共 7 条

[1] SYNTHESIS OF 1,2,4-OXADIAZOLE-DERIVED, 1,3,4-OXADIAZOLE-DERIVED, AND 1,2,4-TRIAZOLE-DERIVED DIPEPTIDOMIMETICS
BORG, S
ESTENNEBOUHTOU, G
LUTHMAN, K
CSOREGH, I
HESSELINK, W
HACKSELL, U
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (10) : 3112 - 3120
[2] OXADIAZOLES AS ESTER BIOISOSTERIC REPLACEMENTS IN COMPOUNDS RELATED TO DISOXARIL - ANTIRHINOVIRUS ACTIVITY
DIANA, GD
VOLKOTS, DL
NITZ, TJ
BAILEY, TR
LONG, MA
VESCIO, N
ALDOUS, S
PEVEAR, DC
DUTKO, FJ
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (15) : 2421 - 2436
[3] SYNTHESE DU DERIVE DIMETHYLE ET DE QUELQUES DERIVES MONOSUBSTITUES DE LOXADIAZOLE-1,2,4
LENAERS, R
MOUSSEBOIS, C
ELOY, F
[J]. HELVETICA CHIMICA ACTA, 1962, 45 (02) : 441 - &
[4] COMPARISON OF AZABICYCLIC ESTERS AND OXADIAZOLES AS LIGANDS FOR THE MUSCARINIC RECEPTOR
ORLEK, BS
BLANEY, FE
BROWN, F
CLARK, MSG
HADLEY, MS
HATCHER, J
RILEY, GJ
ROSENBERG, HE
WADSWORTH, HJ
WYMAN, P
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (09) : 2726 - 2735
[5] IMPROVED SYNTHESIS OF OXADIAZOLES UNDER MICROWAVE IRRADIATION
OUSSAID, B
MOEINI, L
MARTIN, B
VILLEMIN, D
GARRIGUES, B
[J]. SYNTHETIC COMMUNICATIONS, 1995, 25 (10) : 1451 - 1459
[6] TETRAHYDROPYRIDYLOXADIAZOLES - SEMIRIGID MUSCARINIC LIGANDS
SHOWELL, GA
GIBBONS, TL
KNEEN, CO
MACLEOD, AM
MERCHANT, K
SAUNDERS, J
FREEDMAN, SB
PATEL, S
BAKER, R
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (03) : 1086 - 1094
[7] NOVEL BENZODIAZEPINE RECEPTOR PARTIAL AGONISTS - OXADIAZOLYLIMIDAZOBENZODIAZEPINES
WATJEN, F
BAKER, R
ENGELSTOFF, M
HERBERT, R
MACLEOD, A
KNIGHT, A
MERCHANT, K
MOSELEY, J
SAUNDERS, J
SWAIN, CJ
WONG, E
SPRINGER, JP
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (10) : 2282 - 2291

← 1 →