Inflammatory dendritic cells in mice and humans

被引：239

作者：

Segura, Elodie ^{[1
,2
]}

Amigorena, Sebastian ^{[1
,2
]}

机构：

[1] INSERM, U932, F-75005 Paris, France

[2] Inst Curie, Sect Rech, F-75005 Paris, France

来源：

TRENDS IN IMMUNOLOGY | 2013年 / 34卷 / 09期

基金：

欧洲研究理事会;

关键词：

dendritic cells; inflammation; STEADY-STATE; GM-CSF; LY6C(HI) MONOCYTES; ATOPIC-DERMATITIS; LANGERHANS CELLS; FUNGAL-INFECTION; T-CELLS; EXPRESSION; RESPONSES; MACROPHAGES;

D O I：

10.1016/j.it.2013.06.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) are a heterogeneous population of professional antigen-presenting cells. Several murine DC subsets have been identified that differ in their phenotype and functional properties. In the steady state, DC precursors originating from the bone marrow give rise to lymphoid-organ-resident DCs and to migratory tissue DCs. During inflammation, an additional DC subset has been described, so-called inflammatory DCs (infDCs), which differentiate from monocytes recruited to the site of inflammation. Here, we review recent work on the development and functions of murine infDCs. We also examine the criteria that define infDCs. Finally, we discuss the characterization of human infDCs and their potential role in inflammatory diseases.

引用

页码：440 / 445

页数：6

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