Total synthesis of curacin A

被引：30

作者：

Hoemann, MZ ^{[1
]}

Agrios, KA ^{[1
]}

Aube, J ^{[1
]}

机构：

[1] UNIV KANSAS,DEPT MED CHEM,LAWRENCE,KS 66045

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(95)02337-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Curacin A (1) was synthesized in a convergent manner. The key steps were (1) a Julia coupling to establish the stereochemistry of the C(7-10) diene, (2) a Wittig reaction to establish the stereochemistry of the C(3-4) alkene, and (3) a dehydrative cyclization to form the thiazoline ring system.

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页码：953 / 956

页数：4

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