Identification of two putative ATP-cassette genes in Encephalitozoon intestinalis

被引：5

作者：

Bonafonte, MT

Stewart, J

Mead, JR

机构：

[1] Vet Affairs Med Ctr, Decatur, GA 30033 USA

[2] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA 30033 USA

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2001年 / 31卷 / 14期

关键词：

microsporidia; Encephalitozoon intestinalis; ATP cassettes; P-glycoprotein;

D O I：

10.1016/S0020-7519(01)00307-1

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Currently existing chemotherapeutic compounds are limited and few are effective for treating microsporidiosis. It is possible that resistance of Encephalitozoon to some drugs occurs by efflux mechanisms similar to those previously described for mammalian tumour cells, bacteria or protozoal parasites such as Plasmodium, Leishmania and Entamoeba histolytica. The data in the present study suggest that Encephalitozoon intestinalis contains at least one multidrug resistance gene. We report here two complete sequences EiABC1 and EiABC2, encoding different ATP-binding cassette genes from E. intestinalis, including a P-gp. (C) 2001 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：1681 / 1685

页数：5

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