A facile preparation of the methyl 2-thioglycoside of N-glycolylneuraminic acid, an efficient donor of NeuGc

被引：33

作者：

Sugata, T ^{[1
]}

Higuchi, R ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC PHARMACEUT SCI,HIGASHI KU,FUKUOKA 81282,JAPAN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 15期

关键词：

D O I：

10.1016/0040-4039(96)00383-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The methyl 2-thioglycoside of N-glycolylneuraminic acid (SMe-NeuGc, 1), which is an efficient donor of NeuGc in the preparation of sialosyl glycoconjugates, was synthesized from N-acetylneuraminic acid (NeuAc) in 6 steps in good yield. 1 could be glycosylated with two lactose accepters to give sialosyl oligosaccharides 8, 9 and 10 in high yields. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2613 / 2614

页数：2

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