Covalent attachment of novel poly(ethylene glycol)-poly(DL-lactic acid) copolymeric micelles to TiO2 surfaces

被引：38

作者：

Huang, NP

Csucs, G

Emoto, K

Nagasaki, Y

Kataoka, K

Textor, M

Spencer, ND ^{[1
]}

机构：

[1] ETH Zurich, Swiss Fed Inst Technol, Surface Sci & Technol Lab, Dept Mat, CH-8092 Zurich, Switzerland

[2] ETH Zurich, Swiss Fed Inst Technol, Biomech Lab, Dept Mat, CH-8092 Zurich, Switzerland

[3] Sci Univ Tokyo, Dept Mat Sci & Technol, Noda, Chiba 2785180, Japan

[4] Univ Tokyo, Dept Mat Sci, Tokyo 1138656, Japan

来源：

LANGMUIR | 2002年 / 18卷 / 01期

关键词：

D O I：

10.1021/la0109563

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have investigated the attachment of recently developed poly(ethylene glycol)-poly(DL-lactic acid) (PEG-PLA) copolymeric micelles onto functionalized TiO2 and Au. The attachment and immobilization of the micelles were investigated via X-ray photoelectron spectroscopy and reflection-absorption infrared spectroscopy. Protein resistance of the micelle-covered surfaces was tested with optical waveguide lightmode spectroscopy (OWLS). Our results suggest that these PEG-PLA micelles remain stable on the model surface and form a slightly flattened micelle layer with 70% surface coverage. The OWLS studies using human serum albumin as a model protein show that the micelle layer can enhance the protein resistance of the surfaces by up to 70%.

引用

页码：252 / 258

页数：7

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