Synthesis and antitumor activity of goniofufurone analogues

被引：29

作者：

Mereyala, HB ^{[1
]}

Gadikota, RR

Joe, M

Arora, SK

Dastidar, SG

Agarwal, S

机构：

[1] Indian Inst Chem Technol, Div Organ Chem 3, Hyderabad 500007, Andhra Pradesh, India

[2] Ranbaxy Labs Ltd, New Drug Discovery Res, New Delhi 110020, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1999年 / 7卷 / 09期

关键词：

goniofufurone; diastereomers; antitumour; palladium (II) chloride;

D O I：

10.1016/S0968-0896(99)00164-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synthesis and antitumor activity of goniofufurone analogues 15, 16, 17, 33, and 46 is reported. Key step in the synthesis is Pd (II) mediated oxidative cyclisation of vinyl-(hydroxy) furans 18, 19 to the corresponding lactols 32, 43, Cytotoxicities of 15, 16, 17, 33, and 46 tested against six human cancer cell lines are reported. Change of stereochemistry at C-5, C-6 and C-7 position of goniofufurone (1) did not enhance the cytotoxicities significantly. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2095 / 2103

页数：9

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