The CREB/CREM Transcription Factors Negatively Regulate Early Synaptogenesis and Spontaneous Network Activity

被引：25

作者：

Aguado, Fernando ^{[2
]}

Diaz-Ruiz, Carmen ^{[2
]}

Parlato, Rosanna ^{[3
]}

Martinez, Albert

Carmona, Maria A. ^{[2
]}

Bleckmann, Susanne ^{[3
]}

Urena, Jesus M. ^{[2
]}

Burgaya, Ferran ^{[2
]}

del Rio, Jose A. ^{[2
]}

Schutz, Guenther ^{[3
]}

Soriano, Eduardo ^{[1
,2
]}

机构：

[1] Univ Barcelona, Inst Biomed Res, Dept Cell Biol, Lab A1S1, E-08028 Barcelona, Spain

[2] Univ Barcelona, Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, E-08028 Barcelona, Spain

[3] German Canc Res Ctr, D-69120 Heidelberg, Germany

来源：

JOURNAL OF NEUROSCIENCE | 2009年 / 29卷 / 02期

关键词：

CREB/CREM; development; hippocampus; mouse; network activity; synaptogenesis; EYE-SPECIFIC SEGREGATION; ELEMENT-BINDING PROTEIN; NEONATAL HIPPOCAMPUS; CORTICAL CIRCUITS; RETINAL ACTIVITY; AXON GUIDANCE; MICE LACKING; IN-VIVO; CREB; EXPRESSION;

D O I：

10.1523/JNEUROSCI.5252-08.2009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The family of CREB (cAMP response element-binding protein) transcription factors are involved in a variety of biological processes including the development and plasticity of the nervous system. In the maturing and adult brain, CREB genes are required for activity-dependent processes, including synaptogenesis, refinement of connections and long-term potentiation. Here, we use CREB1(Nescre)CREM(-/-) (cAMP-responsive element modulator) mutants to investigate the role of these genes in stimulus-independent patterns of neural activity at early stages. We show that lack of CREB/CREM genes specifically in neural tissue leads to increased synaptogenesis and to a dramatic increase in the levels of spontaneous network activity at embryonic stages. Thus, the functions of CREB/CREM genes in neural activity differ in distinct periods of neural development.

引用

页码：328 / 333

页数：6

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