Pregabalin in clinical psychiatry and addiction: pros and cons

被引：36

作者：

Martinotti, Giovanni ^{[1
]}

机构：

[1] Univ G dAnnunzio, Dept Neurosci & Imaging, I-66013 Chieti, Italy

来源：

EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2012年 / 21卷 / 09期

关键词：

addiction; anxiety; calcium channels; pregabalin; ALCOHOL-WITHDRAWAL SYNDROME; COMPARISON TRIAL; DOUBLE-BLIND; EFFICACY; DEPENDENCE; DISORDER; PLACEBO; SAFETY;

D O I：

10.1517/13543784.2012.703179

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Pregabalin acts as a presynaptic modulator of excitatory neurotransmitter release, binding to the alpha(2)-delta subunit protein of voltage-gated calcium channels. Pregabalin use is becoming widespread in the psychiatric scenario. Data are encouraging, with some good evidence for efficacy in anxious spectrum, benzodiazepine abuse/dependence, and alcoholism. The abuse potential, however, is an issue that should be taken into account, mostly in subjects at risk for developing substance/alcohol misuse.

引用

页码：1243 / 1245

页数：3

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