The combination of polymorphisms within interferon-γ receptor 1 and receptor 2 associated with the risk of systemic lupus erythematosus

被引：48

作者：

Nakashima, H ^{[1
]}

Inoue, H ^{[1
]}

Akahoshi, M ^{[1
]}

Tanaka, Y ^{[1
]}

Yamaoka, K ^{[1
]}

Ogami, E ^{[1
]}

Nagano, S ^{[1
]}

Arinobu, Y ^{[1
]}

Niiro, H ^{[1
]}

Otsuka, T ^{[1
]}

Niho, Y ^{[1
]}

机构：

[1] Kyushu Univ, Fac Med, Dept Internal Med 1, Fukuoka 8128582, Japan

来源：

FEBS LETTERS | 1999年 / 453卷 / 1-2期

关键词：

interferon-gamma receptor 1 (IFN-gamma R1); interferon-gamma receptor 2 (IFN-gamma R2); genetic polymorphism; susceptibility; systemic lupus erythematosus (SLE);

D O I：

10.1016/S0014-5793(99)00701-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic factors seem to play a significant role in susceptibility to systemic lupus erythematosus (SLE), We previously described the amino acid polymorphism (Val14Met) within the IFN-gamma receptor 1 (IFN-gamma R1), and that the frequency of the Met14 allele in SLE patients was significantly higher than that of the healthy control population [Tanaka et al, (1999) Immunogenetics 49, 266-271]. We also found an amino acid polymorphism (Gln64Arg) within IFN-gamma receptor 2 (IFN-gamma R2), Since the IFN-gamma receptor is a complex consisting of IFN-gamma R1 and IFN-gamma R2, we searched for the particular combination of two kinds of amino acid polymorphisms found within the IFN-gamma receptor which plays a prominent role in susceptibility to SLE, The greatest risk of the development of SLE was detected in the individuals who had the combination of IFNGR1 Met14/Val14 genotype and IFNGR2 Gln64/Gln64 genotype. (C) 1999 Federation of European Biochemical Societies.

引用

页码：187 / 190

页数：4

共 9 条

[1] INTERFERONS WITH SPECIAL EMPHASIS ON THE IMMUNE-SYSTEM [J].

FRIEDMAN, RM ;

VOGEL, SN .

ADVANCES IN IMMUNOLOGY, 1983, 34 :97-140

[2]

HEMNI S, 1994, CELL, V76, P803

[3] A SIMPLE MOLECULAR ASSAY FOR THE C-1166 VARIANT OF THE ANGIOTENSIN-II TYPE-1 RECEPTOR GENE [J].

HINGORANI, AD ;

BROWN, MJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 213 (02) :725-729

[4]

LANDOLFO S, 1991, J IMMUNOL RES, V3, P81

[5] A SIMPLIFIED ULTRASENSITIVE SILVER STAIN FOR DETECTING PROTEINS IN POLYACRYLAMIDE GELS [J].

OAKLEY, BR ;

KIRSCH, DR ;

MORRIS, NR .

ANALYTICAL BIOCHEMISTRY, 1980, 105 (02) :361-363

[6]

ROTHERMEL CD, 1983, J IMMUNOL, V131, P2542

[7] RAPID DETECTION OF THE HYPERTENSION-ASSOCIATED MET(235)-] THR ALLELE OF THE HUMAN ANGIOTENSINOGEN GENE [J].

RUSS, AP ;

MAERZ, W ;

RUZICKA, V ;

STEIN, U ;

GROSS, W .

HUMAN MOLECULAR GENETICS, 1993, 2 (05) :609-610

[8] IDENTIFICATION AND SEQUENCE OF AN ACCESSORY FACTOR REQUIRED FOR ACTIVATION OF THE HUMAN INTERFERON-GAMMA RECEPTOR [J].

SOH, J ;

DONNELLY, RJ ;

KOTENKO, S ;

MARIANO, TM ;

COOK, JR ;

WANG, N ;

EMANUEL, S ;

SCHWARTZ, B ;

MIKI, T ;

PESTKA, S .

CELL, 1994, 76 (05) :793-802

[9] Association of the interferon-γ receptor variant (Val14Met) with systemic lupus erythematosus [J].

Tanaka, Y ;

Nakashima, H ;

Hisano, C ;

Kohsaka, T ;

Nemoto, Y ;

Niiro, H ;

Otsuka, T ;

Imamura, T ;

Niho, Y .

IMMUNOGENETICS, 1999, 49 (04) :266-271

← 1 →