Acute lymphoblastic leukaemia

被引：965

作者：

Inaba, Hiroto ^{[1
]}

Greaves, Mel ^{[3
]}

Mullighan, Charles G. ^{[2
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA

[3] Inst Canc Res, Div Mol Pathol, Haematooncol Res Unit, Sutton, Surrey, England

来源：

LANCET | 2013年 / 381卷 / 9881期

基金：

美国国家卫生研究院;

关键词：

MINIMAL RESIDUAL DISEASE; STEM-CELL TRANSPLANTATION; CHILDRENS CANCER GROUP; EVENT-FREE SURVIVAL; T-CELL; STANDARD-RISK; RELAPSE RISK; INTRACHROMOSOMAL AMPLIFICATION; CLINICAL-SIGNIFICANCE; REMISSION INDUCTION;

D O I：

10.1016/S0140-6736(12)62187-4

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Acute lymphoblastic leukaemia occurs in both children and adults but its incidence peaks between 2 and 5 years of age. Causation is multifactorial and exogenous or endogenous exposures, genetic susceptibility, and chance have roles. Survival in paediatric acute lymphoblastic leukaemia has improved to roughly 90% in trials with risk stratification by biological features of leukaemic cells and response to treatment, treatment modification based on patients' pharmacodynamics and pharmacogenomics, and improved supportive care. However, innovative approaches are needed to further improve survival while reducing adverse effects. Prognosis remains poor in infants and adults. Genome-wide profiling of germline and leukaemic cell DNA has identified novel submicroscopic structural genetic changes and sequence mutations that contribute to leukaemogenesis, define new disease subtypes, affect responsiveness to treatment, and might provide novel prognostic markers and therapeutic targets for personalised medicine.

引用

页码：1943 / 1955

页数：13

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