Mitochondrial permeability transition pore and postconditioning

被引：107

作者：

Gateau-Roesch, Odile

Argaud, Laurent

Ovize, Michel

机构：

[1] Univ Lyon 1, Lab Physiol Lyon Nord, Inserm E0226, F-69373 Lyon 08, France

[2] Hop Louis Pradel, Hospices Civils Lyons, F-69437 Lyon 03, France

来源：

CARDIOVASCULAR RESEARCH | 2006年 / 70卷 / 02期

关键词：

ischemia; reperfusion; mitochondria;

D O I：

10.1016/j.cardiores.2006.02.024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Postconditioning has recently been described as a powerful cardioprotection that prevents lethal reperfusion injury. Growing evidence suggests that mitochondial permeability transition may be a key event in postconditioning. This proposition arises from the complementary observations that: (1) conditions for the mitochondrial permeability transition pore (mPTP) opening are built up during early reperfusion, (2) mPTP opens at the time of reperfusion, (3) transgenic structural alteration of mPTP modifies its opening probability following ischemia-reperfusion, (4) mPTP plays a role in preconditioning, and (5) postconditioning attenuates lethal reperfusion injury. We review in this article current evidence for an important role of the mitochondrial transition pore in postconditioning. (c) 2006 European Society of Cardiology. Published by Elsevier B.V All fights reserved.

引用

页码：264 / 273

页数：10

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